Nitin Karandikar, MD, PhD

Professor
Endowed Title: Vernie A. Stembridge, M.D., Distinguished Chair in Pathology
Pathology, Immunology, Neurology and Neurotherapeutics
Graduate Program: Biomedical Engineering
Immunology
Molecular Microbiology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1416
Office Fax: 214-645-6315

nitin.karandikar@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Nitin Karandikar is the Vice Chair of Pathology and the Medical Director of UT Southwestern Clinical Laboratory Services (CLS), which encompasses ambulatory, hospital and reference lab testing for the health system. Dr. Karandikar holds the Vernie A. Stembridge, MD Distinguished Chair in Pathology and is the Director of the Division of Hematopathology and Immunology.

Dr. Karandikar completed his basic medical education in 1990 at the B. J. Medical College, University of Poona, India. After completing a pathology residency at the same institution, he was awarded the prestigious Y. M. Bhende Gold Medal at the post-residency examinations. In addition to a top score, this medal requires unsolicited recommendations from the entire examining panel. During his residency training in India, he developed an interest in scientific research and joined the doctoral program at Northwestern University, Chicago. After getting his Ph.D. in immunology (1997), he completed a clinical pathology residency (1999), a hematopathology fellowship (2000) and postdoctoral immunology research (2001) at UT Southwestern Medical Center.

Dr. Karandikar is on faculty in the departments of pathology, neurology and immunology, directs two clinical fellowship programs and participates in multiple inter-departmental programs. His major research focus is the immune interplay that underlies the pathogenesis and regulation of multiple sclerosis (MS) and the dissection of mechanisms of immune therapies in MS (he held the Harry Weaver Neuroscience Scholar Award of the National MS Society).  He also works on collaborative projects dissecting the immunology of chronic HCV infection, asthma as well as studying allodepletion to minimize graft-versus-host-disease, is an active reviewer for several journals and study sections and has served on multiple national consortia for clinical laboratory and research laboratory collaborations, with focused efforts to making cutting edge research available for clinical assessment and management of patients.  Dr. Karandikar has won teaching awards and has directly mentored over 40 PhD students, fellows, postdocs and junior faculty with a special effort toward mentoring the next generation of disease/patient-oriented physicians and scientists.

Education

FellowshipUT Southwestern Medical Center at Dallas (2000)
ResidencyUT Southwestern Medical Center at Dallas (1999)
Graduate SchoolNorthwestern University Medical School (1997)
UniversityNorthwestern University Medical School (1997)
ResidencyB.J. Medical College (1992)
Medical SchoolByramjee Jeejeebhoy Medical College (1990)
InternshipB.J. Medical College (1989)

Research Interests

Immune regulation of mutliple sclerosis (MS)/autoimmune demyelination

Publications

Featured
High prevalence of autoreactive neuroantigen-specific CD8+ T Cells in multiple sclerosis revealed by novel flow cytometric assay.

Crawford, M.P., S.X. Yan, S. Ortega, R.S. Mehta, R.E. Hewitt, D.A. Price, P. Stastny, D.C. Douek, R.A. Koup, M.K. Racke, and N.J. Karandikar. , Blood , June 2004; (In Press)

Featured
Glatiramer acetate (Copaxone.) induces CD8+ T-cell responses in patients with multiple sclerosis.

Karandikar, N.J., M.P. Crawford, X. Yan, R.B. Ratts, J.M. Brenchley, D.R. Ambrozak, A.E. Lovett-Racke, E.M. Frohman, P. Stastny, D.C. Douek, R.A. Koup, and M.K. Racke. , Journal of Clinical Investigation , 2002; (109):641-649

Featured
CTLA-4: A negative regulator of autoimmune disease.

Karandikar, N.J., C.L. Vanderlugt, T.L. Walunas, S.D. Miller, and J.A. Bluestone. , Journal of Experimental Medicine. , 1996; (184):783-788

Transient Regulatory T-cells: A State Attained by All Activated Human T-cells

V. Pillai, S.B. Ortega, C.K. Wang and N.J. Karandikar , Clinical Immunology , March 2007; (123):18-29

Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs. plasma cell myeloma

A.C. Seegmiller, Y. Xu, R.W. McKenna and N.J. Karandikar , American Journal of Clinical Pathology , February 2007; (127):176-181

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T-cells.

Brenchley, J.M., N.J. Karandikar, M.R. Betts, D.R. Ambrozak, B.J. Hill, L.E. Crotty, J.P. Casazza, J. Kuruppu, S.A. Migueles, M. Connors, M. Roederer, D.C. Douek, and R.A. Koup. , Blood , April 2003; (In Press):Published Online in Nov 2002

Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis

D.K. Tennakoon, R.S. Mehta, S.B. Ortega, V. Bhoj, M.K. Racke and N.J. Karandikar , Journal of Immunology , 2006; (176):7119-29

Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis.

Karandikar, N.J., C.L. Vanderlugt, T. Eagar, L.J. Tan, J.A. Bluestone, and S.D. Miller. , Journal of Immunology. , 1998; (161):192-199

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE.

Miller, S.D., C.L. Vanderlugt, D.J. Lenschow, J.G. Pope, N.J. Karandikar, M.C. Dal Canto, and J.A. Bluestone. , Immunity , 1995; (3):739-745

Honors/Awards

Vernie A. Stembridge Distinguished Chair in Pathology

UT Southwestern (2007)

Harry Weaver Neuroscience Scholar Award

National Multiple Sclerosis Society (2003)

President’s Research Council Distinguished Young Researcher Award

UT Southwestern (2002)

Chief Resident of Pathology

UT Southwestern (2000)

Y. M. Bhende Pathology Gold Medal

Univ. of Poona, India (1993)

Professional Associations/Affiliations

American Association of Immunologists

American Society for Clinical Pathology

American Society of Hematology

College of American Pathologists

Society for Hematopathology