Hong Zhang, PhD

Associate Professor
Biochemistry
Graduate Program: Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

hong.zhang@utsouthwestern.edu

Education

Graduate SchoolUniversity of Illinois Urbana Campus (1994)
UndergraduateUniversity of Science Technology - China (1986)

Research Interests

NAD biosynthesis and regulation
Protein structure and function
Structural biology of RNA interference
Structural mechanisms of mammalian circadian clock

Publications

Featured
Structure of C3PO and mechanism of human RISC activation.

Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H., Nat Struct Mol Biol. , 2011; (18):650-7.

Featured
Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure based drug design and improvement.

Huang, N., Kolhatkar, R., Eyobo, Y., Sorci, L., Rodionova, I., Osterman, A. L., MacKerell, Jr., A. D. and Zhang, H., J. Med. Chem., 2010; (53):5229-5239.

Featured
Structure and function of an ADP-ribose dependent transcriptional regulator of NAD metabolism

Huang, N., De Ingeniis, J., Galeazzi, L., Mancini, C., Korostelev, Y. D., Rakhmaninova, A. B., Gelfand, M. S., Rodionov, D. A., Raffaelli, N. and Zhang, H., Structure, 2009; (17):939-951

Featured
Structure and Mechanism of a Eukaryotic FMN Adenylyltransferase

Huerta, C., Borek, D., Machius, M., Grishin, N. V. and Zhang, H., J. Mol. Biol., 2009; (389):388-400

Featured
Targeting NAD biosynthesis in bacterial pathogens. Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD.

Sorci, L., Pan, Y., Eyobo, Y., Rodionova, I., Huang, N., Kurnasov, O., Zhong, S., MacKerell, Jr., A. D., Zhang, H. and Osterman, A. L., Chem. & Biol., 2009; (16):849-861

Featured
Crystal structure of human riboflavin kinase reveals a b barrel fold and a novel active site arch.

Karthikeyan, S., Zhou, Q., Mseeh, F., Grishin, N. V., Osterman, A. L. and Zhang, H. , Structure , 2003; (11):265-273

Featured
Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis.

Zhang, X., Kurnasov, O. V., Karthikeyan, S., Grishin, N.V., Osterman, A. L. , J. Biol. Chem. , 2003; (278):13503-11

Featured
Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis.

Zhang, X., Kurnasov, O. V., Karthikeyan, S., Grishin, N.V., Osterman, A. L., and Zhang, H. , J. Biol. Chem. , 2003; (278):13503-11

Featured
Crystal structure of human riboflavin kinase reveals a b barrel fold and a novel active site arch

Karthikeyan, S., Zhou, Q., Mseeh, F., Grishin, N. V., Osterman, A. L. and Zhang, H. , Structure , 2003; (11):265-273

Featured
Crystal structure of Rab geranylgeranyl transferase at 2.0E resolution.

Zhang, H., Seabra, M. and Deisenhofer, J. , Structure , 2000; (8):241-251

Professional Associations/Affiliations

American Crystallographic Association

American Society for Biochemistry and Molecular Biology

American Society for Microbiology