Mark Henkemeyer, PhD

Professor
Endowed Title: Dick and Martha Brooks Professorship in Nerve Growth Research
Developmental Biology
Graduate Program: Genetics and Development
Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1951
Office Fax: 214-648-1960

mark.henkemeyer@utsouthwestern.edu

Education

Graduate SchoolUniversity of Wisconsin-Madison (1990)

Publications

Featured
Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning

Xu NJ, Henkemeyer M , Nature Neuroscience , 2009; (12):268-276

Featured
The SH2/SH3 adaptor protein Grb4 transduces B-ephrin reverse signals

Cowan CA, Henkemeyer M , Nature , 2001; (413):174-179

Featured
Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline

Yokoyama N, Romero MI, Cowan CA, Galvan P, Helmbacher F, Charnay P, Parada LF, Henkemeyer M , Neuron , 2001; (29):85-97

Featured
Nuk controls pathfinding of commissural axons in the mammalian central nervous system

Henkemeyer M, Orioli D, Henderson JT, Saxton TM, Roder J, Pawson T, Klein R , Cell , 1996; (86):35-46

Featured
Bidirectional signaling through the Eph family receptor Nuk and its transmembrane ligands

Holland S, Gale N, Mbamalu G, Yancopoulos G, Henkemeyer M, Pawson T , Nature , 1996; (383):722-725

EphB2 tyrosine kinase-dependant forward signaling controls migration of neuronal progenitors that populate and form a distinct region of the dentate niche

Catchpole T, Henkemeyer M , J. Neuroscience , 2011; (in press)

Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues

Dravis C, Henkemeyer, M , Developmental Biology , 2011; (355):138-151

Blocking EphB1 Receptor Forward Signaling in Spinal Cord Relieves Bone Cancer Pain and Rescues Analgesic Effect of Morphine Treatment in Rodents

Liu S, Liu WT, Liu YP, Dong HL, Henkemeyer M, Xiong LZ, Song XJ , Cancer Research , 2011; (in press)

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression

Genander M, Halford MM, Xu NJ, Eriksson M, Yu Z, Qiu Z, Martling A, Greicius G, Thakar S, Catchpole T, Chumley MJ, Zdunek S, Wang C, Holm T, Goff SP, Pettersson S, Pestell RG, Henkemeyer M, Frisen J , Cell , 2009; (139):679-692

Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning

Xu NJ, Henkemeyer M , Nature Neuroscience , 2009; (12):268-276

Honors/Awards

E.I. Du Pont De Nemours & Company graduate student fellowship

1989-1990

Graduated summa cum laude

1984

Medical Research Council of Canada postdoctoral fellowship

1990-1993

National Cancer Institute predoctoral training grant

1984-1989

Rita Allen Foundation Scholar

2002-2005