Dorothy Yuan, PhD

Professor
Pathology
Graduate Program: Immunology
Molecular Microbiology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-4107

dorothy.yuan@utsouthwestern.edu

Biography

My laboratory is interested in understanding the cellular and molecular regulation of immunoglobulin production in response to pathogens. The broad aim of our studies is to further the understanding of the regulatory circuits between two arms of the immune system. Specifically, we are investigating the mechanism by which signals transmitted by natural killer (NK) cells, an important component of the innate immune system, modulate the activation and further differentiation of B lymphocytes, a key player of the specific immune system.

Education

Graduate SchoolUtgsbs (1977)
Graduate SchoolUniversity of Wisconsin-Madison (1965)

Research Interests

Immunology

Publications

Featured
B Cell Induction of IL-13 Expression in NK cells: Role of CD244 and SLAM-associated protein

Gao, N., P. Schwartzberg, J.A. Wilder, B.R. Blazar, and D.Yuan. , Journal of Immunology , March 2006; (176):2758-2764

Featured
Regulatory Role of NK cells on Antibody Responses to Brucella abortus

Gao, N., P. Jennings., Guo, Y., and D. Yuan. , Innate Immunity, 2011; 17 (2):152-163

Featured
Mechanism of induction of NK activation by 2B4 (CD244) via its cognate ligand

Sinha, S. N.Gao, Y.Guo and D. Yuan, Journal of Immunology, 2010; 185 (9):5205-10

Featured
Antigen Specific Responses and ANA production in B6.Sle1b mice: A role for SAP

Jennings, P., A. Chan, P. Schwartzberg, E.K. Wakeland, and D.Yuan , J.Autoimmunity , 2008; (in press)

Featured
Receptors and counterreceptors involved in NK-B cell interactions

Gao, N., T. Dang, W. A. Dunnick, J. T. Collins, B. R. Blazar and D. Yuan. , Journal of Immunology , 2005; (174):4113

Featured
Interactions between NK Cells and B Lymphocytes

Dorothy Yuan , Advances in Immunology , 2004; (84):1-42

Featured
Interferon-g dependent and independent induction of switch recombination by NK cells

Gao, N., T. Dang., and D. Yuan , J. of Immunology , 2001; (167):2011-2018

NK cell enhancement of antigen presentation by B lymphocytes

Jennings, P. , and D. Yuan, Journal of Immunology, 2009; 182 (5):2879-87

Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes.

Gao, N., P. Jennings, and D. Yuan , Int Immunol , 2008; (20):645-657

Taming the Humoral Immune Response to Gram-negative Bacteria.

68. Lu, M, M. Zhang, J. Weiss, M. Apicella, X-H Li, D. Yuan and R.S. Munford , Nature Immunology , 2005; (6):989-994

Professional Associations/Affiliations

American Association of Immunologists

American Association of Science