Masashi Yanagisawa, MD, PhD

Professor
Endowed Title: Patrick E. Haggerty Distinguished Chair in Basic Biomedical Science
Molecular Genetics
Graduate Program: Biomedical Engineering
Integrative Biology
Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2141
Office Fax: 214-648-8804

masashi.yanagisawa@utsouthwestern.edu

Education

Graduate SchoolUniversity of Tsukuba, Pharmacology (1988)

Research Interests

Molecular genetics of sleep/wake regulation
Orphan GPCRs and their neuropeptide ligands

Publications

Featured
Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity

Hiromasa Funato, Allen L. Tsai, Jon T. Willie, Yasushi Kisanuki, S. Clay Williams, Takeshi Sakurai, Masashi Yanagisawa , Cell Metab. , 2009; (9):64-76

Featured
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

Kiminori Hosoda, Robert E. Hammer, James A. Richardson, Amy Greenstein Baynash, Jason C. Cheung, Adel Giaid, Masashi Yanagisawa , Cell , 1994; (79):1267-76

Featured
A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung’s disease

Erik G. Puffenberger, Kiminori Hosoda, Sarah S. Washington, Kazuwa Nakao, Damiane deWit, Masashi Yanagisawa, Aravinda Chakravarti , Cell , 1994; (79):1257-66

Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity.

Funato H, Tsai AL, Willie JT, Kisanuki Y, Williams SC, Sakurai T, Yanagisawa M. , Cell Metab. , January 2009; (9):64-76

Endothelin: 20 years from discovery to therapy.

Barton M, Yanagisawa M. , Can J. Physiol. Pharmacol. , 2008; (86):485-98

An essential role for orexins in emergence from general anesthesia.

Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M. , Proc. Natl. Acad. Sci. USA , 2008; (105):1309-14

The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker.

Mieda M, Williams SC, Richardson JA, Tanaka K, Yanagisawa M. , Proc. Natl. Acad. Sci. USA , 2006; (103):12150-5

Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1.

Yamada T, Ohtani S, Sakurai T, Tsuji T, Kunieda T, Yanagisawa M. , J. Biol. Chem. , 2006; (281):10799-807

Honors/Awards

Bristol-Myers Squibb Achievement Award in Cardiovascular Research

(2003)

Elected Member, National Academy of Sciences

(2003)

The Amgen Award, American Society of Biochemistry and Molecular Biology

(1999)

The Kilby Award, The Kilby Award Foundation

(1998)

The Novartis Award, American Heart Association

(1998)

Professional Associations/Affiliations

Investigator, Howard Hughes Medical Institute