Hiromi Yanagisawa, MD, PhD

Associate Professor
Molecular Biology
Graduate Program: Genetics and Development
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-7723
Office Fax: 214-648-1488

hiromi.yanagisawa@utsouthwestern.edu

Education

Graduate SchoolUniversity of Tsukuba, Medicine (1993)
Graduate SchoolUniversity of Tsukuba, Medicine (1986)

Research Interests

Developmental program of neural crest-derived tissues
ECM and tumor angiogenesis
Elastic fiber formation in vivo
Molecular mechanism of vascular development
Regulation and signaling during cardiovascular remodeling

Publications

Featured
Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo

H. Yanagisawa, E. C. Davis, B. C. Starcher, T. Ouchi, M. Yanagisawa, J. A. Richardson, and E. N. Olson , Nature , January 2002; (415):168-171

Featured
Normal Wound healing in mice deficient for fibulin-5, an elastin binding protein essential for dermal elastic fiber assembly

Q. Zheng, J. Choi, L. Rouleau, R. L. Leask, J. A. Richardson, E. C. Davis, H. Yanagisawa , J. Invest. Derm. , 2006; (126):2707-2714

Featured
Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration

J. A. Spencer, S. L. Hacker, E. C. Davis, R. P. Mecham, R. H. Knutsen, D. Y. Li, R. D. Gerard, J. A. Richardson, E. N. Olson, H. Yanagisawa , Proc. Natl. Acad. Sci. , 2005; (102):2946-2951

Molecular analysis of fibulin-5 function during de novo synthesis of elastic fibers

Q. Zheng, E. C. Davis, J. A. Richardson, B. C. Starcher, T. Li, R. D. Gerard, and H. Yanagisawa , Molecular and Cellular Biology , February 2007; (27):1083-1095

Loss of Fibulin-5 binding to beta1integrins inhibits tumor growth by increasing the level of ROS

M. K. Schluterman, S. L. Chapman, G. Korpanty, K. Ozumi, T. Fukai, H. Yanagisawa, R. A. Brekken , Diseases Models & Mechanisms , 2010; (In press)

Fibulin-2 and Fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury

S. L. Chapman, F.-X. Sicot, E. C. Davis, J. Huang, T. Sasaki, M.-L. Chu, H. Yanagisawa , Arterioscler Thromb Vasc Biol , 2009; (E-Pub.)

Hand proteins control osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2

N. Funato, S. L. Chapman, M. D. McKee, H. Funato, J. A. Morris, J. M. Shelton, J. A. Richardson, H. Yanagisawa , Development , 2009; (136):615-625

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme

A. C. Barbosa, N. Funato, S. L. Chapman, M. D. McKee, J. A. Richardson, E. N. Olson and H. Yanagisawa , Developmental Biology , 2007; (310):154-168

Honors/Awards

Junior Investigator Award

American Society for Matrix Biology (2008)

National Scientist Development Grant (declined)

American Heart Association (2003)

Professional Associations/Affiliations

American Society for Matrix Biology

North American Vascular Biology Organization

Society for Developmental Biology