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Xiao-Song Xie, PhD
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Biography
RESEARCH and PROFESSIONAL EXPERIENCE
1980-1985 Graduate Research Assistant, Department of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY. PhD Thesis Advisor: Efraim Racker, MD
1985-1987 Research Assistant Professor Dept. Internal Medicine, UT Southwestern Medical Center
1987-1990 Assistant Professor, Department of Physiology, UT Southwestern Medical Center
1987-present Member of Graduate Faculty, Graduate Program of Biological Chemistry, UT Southwestern Graduate school of Biomedical Sciences
1990-1998 Associate Professor of Internal Medicine and Physiology Department of Internal Medicine, UT Southwestern
1998-present Professor of Internal Medicine Department of Internal Medicine, UT Southwestern
2001-present Professor of Internal Medicine and Physiology McDermott Center for Human Growth and Development, UT Southwestern
RESEARCH PROJECTS ONGOING OR COMPLETED DURING THE LAST THREE YEARS:
The Structure and Function of Mammalian V-type proton Translocation ATPases.
The long-term goal of this project is to determine the structural basis of the function and regulation of V-type proton pumps. The project characterizes the catalytic center and a regulatory component of the V-type proton pump of clathrin-coated vesicles and studies the isoform structure of the major subunits in its membrane domain to determine the structural basis for the regulation of this pump
Structure and Function of ABCG5 and ABCG8.
The long-term goal of this project is to determine the structure and function of this newly discovered ABC transport system. The project in the current phase is focusing on the purification and biochemical characterization of both native ABCG5/8 transport system and the recombinant proteins
Lipid asymmetry in plasma membrane and Apoptosis-induced PS exposure
The long-term goal of this project is to elucidate the mechanism by which the maintenance of lipid asymmetry in plasma membrane and PS exposure during apoptosis are regulated.
Education
| Graduate School | Cornell University (1985) |
| Undergraduate | Beijing University - China (1975) |
Research Interests
Publications
Jin Wang, Fang Sun, Da-wei Zhang, Yongming Ma, Fang Xu, Jitendra belani, Jonathan Cohen, Helen, Hobbs, and Xiao-Song Xie , Journal of Biologicla Chemistry , September 2006; (Vol. 281):pp.27894-27904
Xiaochen Wang, Jin Wang, Keiko Gengyo-Ando, Lichan Gu, Chen-Ling sun, Chonglin Yang, Yong Shi, TetsuoKobayashi, Yigong Shi, Shohei Mitani, Xiao-Song Xie, and Ding Xue , Nature Cell Biology , May 2007; (Vol. 9):pp.541-549
Marco Gregorini, Jin Wang, Xiao-Song Xie, Ronald, Milligan, Andreas, Engel , Journal of Structural Biology , June 2007; (Vol. 158):pp.27894-27904
Jin Wang, Fang Sun, Da-wei Zhang, Yongming Ma, Fang Xu, Jitendra belani, Jonathan Cohen, Helen, Hobbs, and Xiao-Song Xie , Journal of Biologicla Chemistry , September 2006; (Vol. 281):pp.27894-27904
Crider, B. and Xie, X.-S. , Journal of Biological Chemistry , November 2003; (278):44281-44288
Xiaochen Wang, Jin Wang, Keiko Gengyo-Ando, Lichan Gu, Chen-Ling sun, Chonglin Yang, Yong Shi, TetsuoKobayashi, Yigong Shi, Shohei Mitani, Xiao-Song Xie, and Ding Xue , Nature Cell Biology , May 2007; (Vol. 9):pp.541-549
Xie, X.-S., Padron, D., Liao, X., Wang, J., Roth, M.G., De Brabander, J.K. , Journal of Biological Chemistry , May 2004; (279):19755-19763
Marco Gregorini, Jin Wang, Xiao-Song Xie, Ronald, Milligan, Andreas, Engel , Journal of Structural Biology , June 2007; (Vol. 158):pp.445-454