Richard Wynn, PhD

Associate Professor
Internal Medicine, Biochemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

richard.wynn@utsouthwestern.edu

Education

Graduate SchoolTexas Tech University (1986)
Graduate SchoolTexas Tech University (1983)

Research Interests

Cancer
Diabetes and Glucose metabolism
Heat shock and chaperone proteins
Inborn errors of metabolism
Structure and function of mitochondrial multienzyme complexes

Publications

Featured
Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain {alpha}-Ketoacid Dehydrogenase Complex.

Brautigam CA, Wynn RM, Chuang JL, Naik MT, Young BB, Huang TH, Chuang DT, The Journal of biological chemistry, 2011 Jul; 286 (26):23476-88

Featured
Phenylbutyrate therapy for maple syrup urine disease.

Brunetti-Pierri N, Lanpher B, Erez A, Ananieva EA, Islam M, Marini JC, Sun Q, Yu C, Hegde M, Li J, Wynn RM, Chuang DT, Hutson S, Lee B, Human molecular genetics, 2011 Feb; 20 (4):631-40

Featured
Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.

Padrick SB, Deka RK, Chuang JL, Wynn RM, Chuang DT, Norgard MV, Rosen MK, Brautigam CA, Analytical biochemistry, 2010 Dec; 407 (1):89-103

Featured
Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex

Brautigam, C.A. Wynn, R.M., Chuang, J.L. and Chuang, D.T. , J. Biol Chem. , Winter 2009; (284):13086-13098

Featured
Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity

Wynn, R.M., Kato, M., Chuang, J.L., Tso, S.C., Li, J. and Chuang, D.T. , J. Biol. Chem. , July 2008; (283):25305-25315

Determination of Protein Complex Stoichiometry Though Multisignal Sedimentation Velocity Experiments. Anal Biochem. Jul 24. [Epub ahead of print] PMID: 20667444.

Padrick, S.B., Deka, R.K., Chuang, J.L., Wynn, R.M., Chuang, D.T., Norgard, M.V., Rosen, M.K. and Brautigam, C.A., , ;

Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm).

Islam MM, Nautiyal M, Wynn RM, Mobley JA, Chuang DT, Hutson SM, The Journal of biological chemistry, 2010 Jan; 285 (1):265-76