Ru-Feng Wu, MD, PhD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

ru-feng.wu@utsouthwestern.edu

Education

Graduate SchoolKagawa Medical School (1995)
Graduate SchoolChina Medical University - China (1984)

Research Interests

Cell signal transduction
HIV Tat and Endothelial Cell Dysfunction
Oxidant signaling pathways

Publications

Featured
VEGF causes translocation of p47phox to membrane ruffles through WAVE1

Wu, R.F., Y. Gu, Y.C. Xu, F.E. Nwariaku, and L.S. Terada. , J. Biol. Chem. , September 2003; (278 (38)):36830-36840

Featured
Mutations in the charged residues of the amino terminus of rat liver fructose 6-phosphate,2-kinase: Fructose 2,6-bisphosphatase: Effects on regulation

Wu RF, Uyeda K , ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , November 1999; (371 (1):):15-23

Featured
Porcine FAD-containing monooxygenase metabolizes lidocaine, bupivacaine and propranolol in vitro

Wu, R.F.,(Corresponding author) Liao, C.X., Tomita, S., Ichikawa, Y., Terada, L.S. , Life Sci , July 2004; (75(8)):1011-9

Featured
Human immunodeficiciency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production

Wu, R.F., Y. Gu, Y.C. Xu, S. Mitola, F. Bussolino, and L.S. Terada , J. Virol. , January 2004; (78:(2)):779-789

Featured
Identification of Translin/Trax complex as a glucose response element binding protein in liver

Wu, R.F.,(Corresponding author)Osatomi, K., Trerada, L.S., Uyeda, K , Biochim Biophys Acta , December 2003; (1624(1-3)):29-35

Ras and Nox: linked signaling networks?

Wu RF and Terada LS , Free Radical Biology & Medicine , November 2009; (47 (9)):1278-81

Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation

Wu RF, Ma Z and Terada LS , Mol Cell Biol , July 2010; (14 (30)):3553-3568

HIV1 Tat activates dual Nox pathways leading to independent activation of ERK and JNK MAP kinases.

Wu RF, Ma Z, Myers DP, et al. , JOURNAL OF BIOLOGICAL CHEMISTRY , December 2007; (282 (52)):37412-37419

Subcellular targeting of oxidants during endothelial cell migration

Wu, R.F., Y.C. Xu, Z. Ma, F.E. Nwariaku, G.A, Sarosi, and L.S. Terada , J. Cell Biol , December 2005; (171(5)):893-904

Oxidative modification of protein tyrosine phosphatases.

Wu, R.F., and Terada, L.S., , Sci STKE , April 2006; (2006 (332)):P12

Honors/Awards

Scholar in Scientific Research

ministry of education, science and culture, Japan (1991)