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Woodring Wright, MD, PhD
Endowed Title: Southland Financial Corporation Distinguished Chair in Geriatrics
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-648-2933
Office Fax: 214-648-8694
Biography
Dr. Woodring E. Wright received his BA degree, Summa Cum Laude, from Harvard University in 1970, a PhD under the direction of Dr. Leonard Hayflick in 1974 and an MD from Stanford University School of Medicine in 1975. Following a postdoctoral fellowship at the Pasteur Institute in Paris, France with Dr. Francois Gros, he joined the faculty at Southwestern Medical School in Dallas, Texas in 1978, where he is now Professor of Cell Biology and Southland Financial Corporation Distinguished Chair in Geriatric Research.
Dr. Wright has been the recipient of the Lyndon Baines Johnson Research Award of the American Heart Association, a Research Career Development award from the NIH, a Merit Award from the National Institute on Aging, an AlliedSignal Award for Research on Aging, the Hayflick Award from American Aging Association and an Ellison Medical Foundation Senior Scholar Award. He is on the Scientific Advisory Board of the Buck Institute on Aging. He is the author of more than 200 scientific publications, and holds fifteen U.S. patents, with an additional eight pending.
Telomere shortening ultimately limits the number of times normal human cells are able to divide before they reach replicative senescence. Dr. Wright and his colleague Dr. Jerry Shay have found that preventing telomere shortening by expressing the catalytic subunit of telomerase in normal diploid cells is able to immortalize many different cells. He is exploring the molecular mechanisms regulating telomere shortening and telomerase action, and pursuing a variety of approaches to exploit these insights for the treatment of cancer and age-related diseases.
Education
| Graduate School | Stanford University (1975) |
| Graduate School | Stanford University (1974) |
Research Interests
Publications
Sfeir, A. J., Chai, W., Shay, J. W., and Wright, W. E. , Mol Cell , 2005; (18):131-138
Steinert, S., J. W. Shay and W. E. Wright , Mol Cell Biol , 2004; (24(10)):4571-4580
Baur, J.A., Y. Zou, J.W. Shay, and W.E. Wright , Science , 2001; (292/5524):2075-2077
Herbert, B., A.E. Pitts, S.I. Baker, S.E. Hamilton, W.E. Wright, J.W. Shay, and D.R. Corey , Proc Natl Acad Sci U S A , 1999; (96/25):14276-14281
Bodnar, A.G., M. Ouellette, M. Frolkis, S.E. Holt, C.P. Chiu, G.B. Morin, C.B. Harley, J.W. Shay, S. Lichtsteiner, and W.E. Wright , Science , 1998; (279/5349):349-352
Shay, J.W. and W.E. Wright , J Pathology , 2007; (211):114-123
Chai, W., A. J. Sfeir, H. Hoshiyama, J. W. Shay and W. E. Wright , EMBO Rep , 2006; (7):225-230
Chai, W., Q. Du, J. W. Shay and W. E. Wright , Mol Cell , 2006; (21):427-435
Wright, W. E., and Shay, J. W. , Nat Genet , 2005; (17):116-118
Bechter, O. E., Y. Zou, J. W. Shay and W. E. Wright , EMBO Rep , 2003; (4(12)):1138-1143
Related Links
Honors/Awards
American Federation for Aging Research (2009)
Senior Scholar Award in Aging (2002)
Award for Research on Aging (2001)
Hayflick Award (2001)
Scientific Advisory Board (1999)