Thomas Wilkie, PhD

Associate Professor
Pharmacology
Graduate Program: Genetics and Development
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6127
Office Fax: 214-645-6131

thomas.wilkie@utsouthwestern.edu

Biography

Education

1980 BA, Biochemistry Department, University of California, Berkeley

1987 PhD, Biochemistry Department, University of Washington, with Dr. Richard D. Palmiter Thesis: Transmission Ratio Distortion and Mosaicism in Transgenic Mice Postdoctoral Training 1986-1992 NIH Postdoctoral Fellow with Dr. Melvin I. Simon California Institute of Technology, Pasadena CA

Academic Appointments

1993 Assistant Professor, Department of Pharmacology

2000 Associate Professor, Department of Pharmacology

Education

Graduate SchoolUniversity of Washington, Biochemistry (1986)
UndergraduateUniversity of California-Berkeley, Biochemistry (1980)

Research Interests

G Protein Signaling in Pancreas Development, Adult Physiology and Behavior
Pancreas cancer
Pancreatic ductal adenocarcinoma
Pancreatic islet and beta cell expansion in diabetes

Publications

Featured
Ca2+/calmodulin reverses 3,4,5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.

Popov S, Krishna UM, Falck JR & Wilkie TM , J. Biol. Chem. , 2000; (275):18962-18968

Featured
GTPase-activating proteins (GAPs) for heterotrimeric G proteins: Regulators of G protein signaling (RGS proteins) and their relatives.

Ross EM & Wilkie TM , Annual Review of Biochemistry , 2000; (69):795-827

Featured
The N-terminal domain of RGS4 confers receptor selective inhibition of G protein signaling

Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff K, Fisher S, Ross EM, Muallem S & Wilkie TM , J. Biol. Chem. , 1998; (273):34687-34690

Featured
The RGS domains of RGS4, RGS10 and GAIP retain GAP activity in vitro.

Popov S, Yu K, Kozasa T & Wilkie TM , Proc. Natl. Acad Sci. USA , 1997; (94):7216-7220

Featured
GAIP and RGS4 are GTPase accelerating proteins (GAPs) for the Gi family of heterotrimeric guanine nucleotide binding proteins.

Berman DM, Wilkie TM & Gilman AG , Cell , 1996; (86):445-452

Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes

Villasenor A, Wang ZV, Rivera LB, Ocal O, Wernstedt Asterholm I, Scherer PE, Brekken RA, Cleaver O*, & Wilkie TM* , Disease Models & Mechanisms , September 2010; (3):567-580

New roles for Ga and RGS proteins: Communication continues despite driving sisters apart.

Wilkie TM & Kinch L. , Current Biology , November 2005; (15):R843-R854

Regulator of G protein Signaling (Rgs16) inhibits hepatic fatty acid oxidation in a ChREBP-dependent manner

Pashkov V*, Huang J*, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Gerard RD, Esser V, Uyeda K, Towle H & Wilkie TM , J Biol Chem , April 2011; (286 [Cover]):15116-15127

G alpha-q and Galpha-11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.

Ivey K, Tyson B, Ukidwe P, McFadden D, Levi G, Olson E, Srivastava D & Wilkie TM , Developmental Biology , 2003; (255):230-237

Regulators of G protein signaling provide biochemical control of agonist-evoked [Ca2+]i oscillations.

Luo X, Popov S, Bera AK, Wilkie TM & Muallem S , Molecular Cell , 2001; (7):651-660

Honors/Awards

Editorial Board

Nature Molecule Pages (2011)

Editorial Board

Journal of Biological Chemistry (2007)

NIH and AHA

Study Section, Reviewer (2004)

Established Investigator Award

American Heart Association (1996)

Basil OConner MOD

Starter Scholar Research Award (1995)