E Sally Ward Ober, PhD

Professor
Endowed Title: Paul and Betty Meek-FINA Professorship in Molecular Immunology
Immunology, Cancer Immunobiology Center
Graduate Program: Biomedical Engineering
Immunology
Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1260
Office Fax: 214-648-1259

sally.ward@utsouthwestern.edu

Education

Graduate SchoolCambridge University - England (1986)

Publications

Featured
Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels,

Vaccaro, C., Zhou, J., Ober, R.J. and Ward, E.S. , Nature Biotechnology , 2005; (23):1283-1288

Featured
Molecular requirements for T cell recognition by an MHC Class II restricted T cell receptor: the involvement of the fourth hypervariable loop of the Vα domain,

Thatte, J., Qadri, A., Radu, C. and Ward, E.S. , Journal of Experimental Medicine , 1999; (189):509-519

Featured
Increasing the serum persistence of an IgG fragment by random mutagenesis,

Ghetie, V., Popov, S., Borvak, J., Radu, C., Matesoi, D., Medesan, C., Ober, R.J. and Ward, E.S. , Nature Biotechnology , 1997; (15):637-640

Featured
Crystal structure of the Vα domain of a T cell antigen receptor,

Fields, B.A., Ober, B., Malchiodi, E.L., Lebedeva, M.I., Braden, B., Ysern, X., Kim, J-K., Shao, X., Ward, E.S. and Mariuzza, R.A. , Science , 1995; (270):1821-1824

Featured
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli,

Ward, E.S., Gussow, D., Griffiths, A., Jones, P.T. and Winter, G. , Nature , 1989; (341):544-546

Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy

Prabhat P, Gan, Z., Chao, J., Ram, S., Vaccaro, C., Gibbons, S., Ober, R.J. and Ward, E.S. , Proceedings of the National Academy of Sciences , 2007; (104)

Beyond Rayleigh′s criterion: a resolution measure with application to single molecule microscopy,

Ram, S., Ward, E.S. and Ober, R.J. , Proceedings of the National Academy of Sciences , 2006; (103):4457-4462

Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies

Vaccaro, C., Bawdon, R., Wanjie, S., Ober, R.J., and Ward, E.S. , Proceedings of the National Academy of Sciences , 2006; (103):18709-18714

From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling,

Ward, E.S., Martinez, C., Vaccaro, C., Zhou, J., Tang, Q. and Ober, R.J. , Molecular Biology of the Cell , 2005; (16):2028-2038

Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level,

Ober, R.J., Martinez, C., Lai, X., Zhou, J. and Ward, E.S. , Proceedings of the National Academy of Sciences , 2004; (101):11076-11081