Alan Varley, PhD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

alan.varley@utsouthwestern.edu

Education

Graduate SchoolKansas University, Microbiology (1992)
Graduate SchoolKansas University (1985)
UndergraduateAuburn University, Biology (1978)

Research Interests

Application of Physiologically-regulated Gene Therapy to Inflammatory Diseases

Publications

Featured
A Two-Component Expression System that Responds to Inflammatory Stimuli in Vivo

Varley AW, Geiszler SM, Gaynor RB, Munford RS , Nature Biotechnology , October 1997; (15 (10)):1002-1006

Featured
Inflammation-Induced Recombinant Protein Expression in Vivo using Promoters from Acute-Phase Protein Genes

Varley AW, Coulthard MG, Meidell RS, Gerard RD, Munford RS , Proceedings of the National Academy of Sciences of the United States of America , June 1995; (92 (12)):5346-5350

Featured
Cell Division Genes of Bacillus subtilis: The minicell locus (divIVB) encodes septum placement (min) and cell shape determinants (mre)

Department of Microbiology , The University of Texas Southwestern Medical Center , 1993;

Featured
Cloning and Molecular Analysis of the divIVB Locus of B.subtilis

Seminar, Microbiology Seminar Series , USC School of Medicine , 1992;

Physiologically Responsive Gene Therapy

Varley AW, Munford RS , Molecular Medicine Today , October 1998; (4 (10)):445-451

Endogenous Regulation of a Therapeutic Transgene Restores Homeostasis in Arthritic Joints

Miagkov AV, Varley AW, Munford RS, Makarov SS , Journal of Clinical Investigation , May 2002; (109 (9)):1223-1229

Gene Therapy to Prevent Organophosphate Intoxication

Cowan J, Sinton CM, Varley AW, Wians FH, Haley RW, Munford RS , Toxicology and Applied Pharmacology , May 2001; (173 (1)):1-6

C3-Tat/HIV-Regulated Intraarticular Human Interleukin-1 Receptor Antagonist Gene Therapy Results in Efficient Inhibition of Collagen-Induced Arthritis Superior to Cytomegalovirus-Regulated Expression of the Same Transgene

Bakker, AC, van de Loo FAJ, Joosten LAB, Arntz OJ, Varley AW, Munford RS, van den Berg WB , Arthritis and Rheumatism , June 2002; (46 (6)):1661-1670

Professional Associations/Affiliations

American Association for the Advancement of Science

American Society for Microbiology

Inflammation Research Association

Society for Critical Care Medicine