Kosaku Uyeda, PhD

Professor
Endowed Title: Bonnie Bell Harding Professorship in Biochemistry
Biochemistry, Internal Medicine
Graduate Program: Biological Chemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

kosaku.uyeda@utsouthwestern.edu

Education

Graduate SchoolUniversity of California-Berkeley (1962)
Graduate SchoolOregon State University (1957)

Research Interests

Glucose signaling pathway and its signaling mechanism in lipogenesis.
Long term regulation which includes transcriptional controls by hormones, nutrients and stress factors.
Regulation of carbohydrate metabolism and lipogenesis in various mammalian tissues.
Short term regulation such as allosteric controls of key enzymes in glucose metabolism and fat synthesis.

Publications

Featured
Carbohydrate-response element-binding protein deletion alters substrate utilization producing and energy-deficient liver

Burgess, SC, Iizuka, K, Jeoung,NH, Harris, RA, Kahsiwaya, Y, Veech, RL, Kitazume, T., and Uyeda, K , J. Biol. Chem. , January 2008; (283):1670-1678

Featured
Glucose and cAMP Regulate L-type Pyruvate Kinase Gene by Phosphorylation/Dephosphorylation of the Carbohydrate Response Element Binding Protein.

Kawaguchi, T., Takenoshita, M., Kabashima, T., and Uyeda, K. , Proc. Natl..Acad. Sci. , 2001; (98):13710  13715

Featured
A Glucose-Responsive Transcription Factor that regulates Carbohydrate Metabolism in the liver.

Yamashita, H.,Takenoshita, M., Sakurai, M., Bruick, R.K., Henzel, W.J., Shillinglaw, W., Arnot, D., and Uyeda, K. , Proc Natl. Acad. Sci. , 2001; (98):9116-9121

Featured
Crystallization and Preliminary X-ray Analysis of Fructose 6-phosphate,2-kinase:Fructose 2,6-bisphosphatase.

Istvan, E.S., Hasemann, C.A., Kurumbail, R.G., Uyeda, K., and Deisenhofer, J. , Protein Sci. , 1995; (4):2439-2441

Featured
Catalyzing Dephosphorylation of Fructose 6-phosphate,2-kinase:Fructose 2,6-bisphosphatase

Nishimura, M. and Uyeda, K. , J. Biol. Chem. , 1995; (270):9116-9121

Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP)

Sakiyamam H, Wynn, RM, Lee, WR, Fukasawa, M, Mizuguchi, H, Gardner, KH, Repa, JJ, and Uyeda,K , J Biol. Chem. , September 2008; (283):24899-24908

Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.

Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K. , Proc. Natl. Acad. Sci. USA , May 2003; (100(10)):5578-80

Carbohydrate-response element-binding protein deletion alters substrrate utilization producing an energy-deficient liver

Burgess, SC, Iizuka, K., Jeoung, NH, Harris, RA, Kashiwaya, Y, Veech, RL, Kitazume, T, and Uyeda, K., , J. Biol. Chem , 2008; (283):1670-1678

Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis.

Uyeda, K., and Repa, J.J. , Cell Metabolism , 2006; (4):107-110

Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.

Iizuka, K., Miller, B., and Uyeda, K. , Am. J. of Physiol. Endcrinol. Metab. , 2006; (291):E358-E364

Honors/Awards

William S. Middleton Award

(1984)

Professional Associations/Affiliations

American Association for the Advancement of Science

American Chemical Society

American Society of Biological Chemists