Stephen Turley, PhD

Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

stephen.turley@utsouthwestern.edu

Biography

Dr. Turley is research professor in the Department of Internal Medicine. He received his Ph.D. from the Australian National University and then completed three years of postdoctoral training in the Department of Internal Medicine at the University of Texas Health Science Center in Dallas in 1979.

Dr. Turley’s research interests focus mainly on three areas of cholesterol metabolism. One of these relates to the mechanisms that regulate sterol absorption. The second area is the regulation and quantitative importance of the two main pathways by which the liver converts cholesterol to bile acids. These studies are utilizing mice deficient in either cholesterol 7alpha-hydroxylase or sterol 27-hydroxylase. The third area of interest relates to the regulation of cholesterol metabolism in the brain during fetal and neonatal development. Dr. Turley gives frequent lectures and has published extensively on these topics.

Education

Graduate SchoolAustralian National University - Australia (1976)
UndergraduateUniversity of New England (1972)

Research Interests

bile acid metabolism
cholesterol metabolism
gallstone disease
heart disease
sterol absorption

Publications

Featured
Genetic variations and treatments that affect the lifespan of the NPC1 mouse

Liu, B., Li H., Repa, J.J., Turley, S.D., Dietschy, J.M. , J Lipid Res , Winter 2008; (49):663-669

Featured
Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia: reversal by cholic acid feeding

Repa, J.J., Lund, E.G., Horton, J.D., Leitersdorf, E., Russell, D.W., Dietschy, J.D. and Turley, S.D. , J. Biol. Chem. , 2000; (275):39685-39692

Featured
Identification of a metabolic difference accounting for the hyper- and hyporesponder phenotypes of cynomolgus monkey

Turley, S.D., Spady, D.K. and Dietschy, J.M. , J. Lipid Res. , 1997; (38):1598-1611

Featured
Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep

Turley, S.D., Burns, D.K., Rosenfeld, C.R. and Dietschy, J.M. , J. Lipid Res. , 1996; (37):1953-1961

Featured
The contribution of newly synthesized cholesterol to biliary cholesterol in the rat

Turley, S.D. and Dietschy, J.M. , J. Biol. Chem. , 1981; (256):2438-2446

Lysosomal unesterified cholesterol content correlates with liver cell death in murine Niemann-Pick type C disease

Beltroy, E.P., Liu, B., Dietschy, J.M., Turley, S.D. , J Lipid Res , Summer 2007; (48):869-881

Role of Niemann-Pick C1-like 1 (NPC1L1) in intestinal sterol absorption

Turley, S.D. , J Clin Lipidol , March 2008; (2):S20-S28

Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption

Repa, J.J., Turley, S.D., Quan, G. and Dietschy, J.M. , J. Lipid Res. , 2005; (46):779-789

Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse

Garver, W.S., Xie, C., Repa, J.J., Turley, S.D., Dietschy, J,M. , J. Lipid Res. , 2005; (46):1745-1754

Cholesterol accumulation and liver cell death in the mouse with Niemann-Pick type C disease

Beltroy, E.P., Richardson, J.A., Horton, J.D., Turley, S.D., Dietschy, J.M. , Hepatology , 2005; (42):886-893