Philip Thorpe, PhD

Professor
Endowed Title: Serena S. Simmons Distinguished Chair in Cancer Immunopharmacology
Pharmacology, Simmons Comprehensive Cancer Center
Graduate Program: Cancer Biology
Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1268
Office Fax: 214-648-1613

philip.thorpe@utsouthwestern.edu

Biography

EDUCATION/TRAINING

University of Liverpool, UK BSc 1972 Pharmacology

 Clinical Research Centre, London, UK PhD 1976 Immunology

POSITIONS AND EMPLOYMENT

1975-1981 Medical Research Council Fellow, Chester Beatty Research Institute, London, UK

1981-1991 Director, Drug Targeting Laboratory, Imperial Cancer Research Fund, London, UK

1991-1998 Professor of Pharmacology, UT Southwestern Medical Center

1998-1999 Associate Director, Center for Molecular Medicine, Maine Medical Center, ME

1999-Present Serena Simmons Distinguished Chair in Cancer Immunopharmacology, Professor of Pharmacology, UT Southwestern

OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS

1998 Chairman, Gordon Research Conference on Drug Carriers in Medicine and Biology, Ventura, CA

2002 Chairman, 1st International Symposium on Vascular Targeting, Boston, MA

2004 Chairman, 2nd International Symposium on Vascular Targeting, Miami, FL

2004-Present American Cancer Society Institutional Review Group Honors

1972 1st Class honors (summa cum laude), Bachelor of Science Degree

1988 1st recipient of Pierce Immunotoxin Award (awarded every two years for outstanding contributions to immunotoxin research)

1997 Texas State Legislature Award for Research Excellence 1999 American Cancer Society Award of Excellence

PATENTS

 252 issued and pending worldwide patents (including 74 in the US)

PUBLICATIONS

200 publications in fields of drug targeting, angiogenesis, antibody-based therapeutics.

 

Education

Graduate SchoolUniversity of London - England (1975)
UndergraduateUniversity of Liverpool - England (1972)

Research Interests

Angiogenesis and anti-angiogenic therapeutics
Anti-viral therapeutics that target host determinants on virally infected cells
Antibody-drug conjugates and immunotoxins
Development of novel phosphatidylserine-targeting thererapeutics
Imaging cancer for prediction of tumor response to therapy
Phosphatidylserine
Regulation of tumor immunosuppression
Vascular targeting agents

Publications

Featured
Increased exposure of anionic phospholipids on the surface of tumor blood vessels

Ran S, Downes A, Thorpe PE , Cancer Research , 2002; (62):6132-6140

Featured
In vitro and in vivo studies of a VEGF-121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

Veenendaal LM, Jin H, Ran S, Cheung L, Navone N, Marks JW, Thorpe PE, Walterberger J, Rosenblum MG , Proceedings of the National Academies of Science (USA) , 2002; (99):7866-7871

Featured
Vascular endothelial growth factor as a marker of tumor endothelium

Brekken RA, King SW, Thorpe PE , Cancer Research , 1998; (58):1952-1959

Featured
Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature

Huang X, Molema G, King S, Watkins L, Edgington TS, Thorpe PE , Science , 1997; (275):547-550

Featured
Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature

Burrows FJ, Thorpe PE , Proceedings of the National Academies of Science (USA) , 1993; (90):8996-9000

Development of novel CXCR4-based therapeutics.

Peled A, Wald O, Burger J, Expert opinion on investigational drugs, 2012 Mar; 21 (3):341-53

Increased exposure of phosphatidylethanolamine on the surface of tumor vascular endothelium.

Stafford JH, Thorpe PE, Neoplasia (New York, N.Y.), 2011 Apr; 13 (4):299-308

Co-localization of prothrombin fragment F1+2 and VEGF-R2-bound VEGF in human colon cancer.

Sierko E, Wojtukiewicz MZ, Zimnoch L, Thorpe PE, Brekken RA, Kisiel W, Anticancer research, 2011 Mar; 31 (3):843-7

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via ß2GPI and apoER2.

Ramesh S, Morrell CN, Tarango C, Thomas GD, Yuhanna IS, Girardi G, Herz J, Urbanus RT, de Groot PG, Thorpe PE, Salmon JE, Shaul PW, Mineo C, The Journal of clinical investigation, 2011 Jan; 121 (1):120-31

Honors/Awards

American Cancer Society Award of Excellence

(1999)

Texas State Legislature Award for Research Excellence

(1997)

1st recipient of Pierce Immunotoxin Award

awarded every two years for outstanding contributions to immunotoxin research (1988)

1st Class honors (summa cum laude)

Bachelor of Science Degree (1972)

Professional Associations/Affiliations

Amer. Society for Pharmacology & Experimental Therapeutics

American Association for Cancer Research

American Association for Immunology

North American Vascular Biology Organization

Sigma Xi