Dwain Thiele, MD

Senior Associate Dean
Professor
Endowed Title: Jan and Henri Bromberg Chair in Internal Medicine
Office of the Dean - Southwestern Medical School, Internal Medicine
Graduate Program: Immunology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

dwain.thiele@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Thiele joined the Department of Internal Medicine in 1983, and the Graduate Program in Immunology in the Graduate School of Biomedical Sciences in 1986. He served as Chief of Hepatology from 1998-2005, Interim Chief of the Division of Digestive and Liver Diseases from 2002-2005,Vice Chair for Financial Affairs, Department of Internal Medicine from 2005-2010 and as Interim Chair, Department of Internal Medicine, 2009-2010 before assuming his current position as a Senior Associate Dean. Dr. Thiele has broad interests in clinical hepatology, with special interests in acute viral hepatitis, autoimmune hepatitis and acute hepatitis of unknown etiology. Research conducted in Dr. Thiele’s laboratory focuses on delineating mechanisms of cytotoxic lymphocyte activation, differentiation and effector function, and exploring the role of these immune effector mechanisms in clearance of viral infections from the liver.

Education

FellowshipUT Southwestern Medical Center, Gastroenterology and Liver Diseases (1983)
ResidencyDuke University School of Medicine, Internal Medicine (1980)
Medical SchoolBaylor College of Medicine (1977)

Research Interests

Antiviral immune responses
Cytotoxic lymphocyte function
Transplantation immunology

Publications

Featured
A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8(+) T cell cytotoxic effector function

Thiele DL, McGuire MJ and Lipsky PE , J. Immunol. , 1997; (158):5200-5210

Featured
Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I

McGuire MJ, Lipsky PE and Thiele DL , J. Biol. Chem. , 1993; (268):2458-2467

Featured
The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I mediated conversion to membranolytic products

Thiele DL and Lipsky PE , J. Exp. Med. , 1990; (172):183-194

Featured
Intestinal graft versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes

Thiele DL, Eigenbrodt ML, Bryde SE, Eigenbrodt EH and Lipsky PE , J. Clin. Invest. , 1989; (84):1947-1956

Featured
Regulation of cellular function by products of lysosomal enzyme activity: Elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes

Thiele DL and Lipsky PE , Proc. Natl. Acad. Sci. USA , 1985; (82):2468-2472

The role of serpinB9 / serine protease inhibitor 6 in preventing granzyme B dependent hepatotoxicity

Stout-Delgado HW, Y Getachew, TE Rogers, BC Miller and DL Thiele , Hepatology , 2007; (45):In Press

Intrahepatic Lymphocyte Expression of Dipeptidyl Peptidase I Processed Granzyme B and Perforin Induces Hepatocyte Expression of Serine Proteinase Inhibitor 6 (Serpinb9/SPI-6).

74. Stout-Delgado HW, Y Getachew, BC Miller and DL Thiele , J. Immunol. , 2007; (179):6561-6567

Fas and TNFR1 but not cytolytic granule dependent mechanisms mediate clearance of liver adenovirus infection

Abougergi MC, SJ Gidner, DK Spady, BC Miller and DL Thiele , Hepatology , 2004; (41):97-102

Anti-viral cytokines induce hepatic expression of the granzyme B inhibitors proteinase inhibitor 9 and serine proteinase inhibitor 6

Barrie MB, HW Stout, MS Abougergi, BC Miller and DL Thiele , J Immunol , 2004; (172):6453-6459

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB and Thiele DL , Proc Natl Acad Sci U S A , 2003; (100):6221-6226

Honors/Awards

American Association of Physicians

(2004)

Teacher of the Year, UT Southwestern Gastroenterology Training Program

(2000)

American Society for Clinical Investigation

(1997)

Best Doctors in America

(1996)

Teacher of the Year, UT Southwestern Gastroenterology Training Program

(1994)

Professional Associations/Affiliations

American Association for Immunologists

American Association for the Study of Liver Diseases

American Gastroenterological Association