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Paul Sternweis, PhD
Endowed Title: Alfred and Mabel Gilman Chair in Molecular Pharmacology
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-645-6149
Office Fax: 214-645-6151
Biography
Dr. Paul C. Sternweis received his BA.in Chemistry (summa cum laude) from the College of St. Thomas (St. Paul, MN.) and his PhD in Biochemistry in 1977 with Dr. Leon Heppel at Cornell University (Ithaca, N.Y.). His graduate thesis focused on the elucidation of molecular mechanisms of the proton-translocating ATPase in Escherichia coli. As a postdoctoral fellow with Dr. Alfred Gilman, Dr. Sternweis began working on mammalian systems and contributed to the discovery, purification and characterization of the first G protein, Gs, that is responsible for hormonal regulation of adenylyl cyclase.
In 1982, Dr. Sternweis became an assistant professor of pharmacology at UT Southwestern, where he has risen to the rank of full professor and currently holds the Alfred and Mabel Gilman Chair in Molecular Pharmacology. During this time, Dr. Sternweis has continued to work on the mechanisms of hormonal signaling with a focus on G protein-dependent mechanisms including the identification of novel G proteins, regulation of phospholipases that produce lipid-derived second messengers and pathways that lead to the monomeric GTPases involved in cell architecture and movement.
Dr. Sternweis has served as Division Chair of the Molecular Pharmacology Division of ASPET and served on various review panels, including current chair of a basic review panel for AHA. He chaired the Graduate Admissions committee for several years and coordinates the Signal Transduction course among other teaching responsibilities. He currently chairs the Cell Regulation graduate program.
Education
| Graduate School | Cornell University (1977) |
| Undergraduate | College of St. Thomas (1972) |
Research Interests
Publications
Chen Z, Medina F, Liu MY, Thomas C, Sprang SR, Sternweis PC, The Journal of biological chemistry, 2010 Jul; 285 (27):21070-81
Hsueh RC, Natarajan M, Fraser I, Pond B, Liu J, Mumby S, Han H, Jiang LI, Simon MI, Taussig R, Sternweis PC, Science signaling, 2009 ; 2 (71):ra22
Chen, Z, Singer, W.D., Danesh, S.M., Sternweis, P.C., Sprang, S.R. , Structure , October 2008; (16):1532-1543
Jiang LI, Collins J, Davis R, Lin KM, DeCamp D, Roach T, Hsueh R, Rebres RA, Ross EM, Taussig R, Fraser I, Sternweis PC, The Journal of biological chemistry, 2007 Apr; 282 (14):10576-84
Chen Z, Guo L, Sprang SR, Sternweis PC, Protein science : a publication of the Protein Society, 2011 Jan; 20 (1):107-17
Jiang LI, Collins J, Davis R, Fraser ID, Sternweis PC, The Journal of biological chemistry, 2008 Aug; 283 (34):23429-39
Sternweis PC, Carter AM, Chen Z, Danesh SM, Hsiung YF, Singer WD, Advances in protein chemistry, 2007 ; 74:189-228
Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G, Science (New York, N.Y.), 1998 Jun; 280 (5372):2112-4
Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC, Science (New York, N.Y.), 1998 Jun; 280 (5372):2109-11
Natarajan, M., Lin, K-M., Hsueh, R.C., Sternweis, P.C., Ranganathan, R. , Nat. Cell Biol. , June 2006; (8):571-80
Related Links
Honors/Awards
Alfred and Mabel Gilman Chair in Molecular Pharmacology, 2000-present
American Heart Association, 1986-1991
1983-1986