William Snell, PhD

Professor
Cell Biology
Graduate Program: Cell Regulation
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2570
Office Fax: 214-648-8694

william.snell@utsouthwestern.edu

Education

Graduate SchoolYale University (1975)
Graduate SchoolYale University (1969)

Research Interests

Cellular and molecular mechanisms of cell-cell fusion
Cilium-generated signaling and intraflagellar transport
Malaria vaccines
The biology of cilia and flagella

Publications

Featured
Chlamydomonas shortens its flagella by activating axonemal disassembly, stimulating IFT particle trafficking, and blocking anterograde cargo loading.

Pan J, Snell WJ, Developmental cell, 2005 Sep; 9 (3):431-8

The phosphorylation state of an aurora-like kinase marks the length of growing flagella in Chlamydomonas.

Luo M, Cao M, Kan Y, Li G, Snell W, Pan J, Current biology : CB, 2011 Apr; 21 (7):586-91

Membrane fusion triggers rapid degradation of two gamete-specific, fusion-essential proteins in a membrane block to polygamy in Chlamydomonas.

Liu Y, Misamore MJ, Snell WJ, Development (Cambridge, England), 2010 May; 137 (9):1473-81

The ciliary membrane.

Rohatgi R, Snell WJ, Current opinion in cell biology, 2010 Aug; 22 (4):541-6

SnapShot: Intraflagellar transport.

Cole DG, Snell WJ, Cell, 2009 May; 137 (4):784-784.e1

A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas.

Piao T, Luo M, Wang L, Guo Y, Li D, Li P, Snell WJ, Pan J, Proceedings of the National Academy of Sciences of the United States of America, 2009 Mar; 106 (12):4713-8

Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm.

Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P, Molecular reproduction and development, 2009 Dec; 76 (12):1188-99

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes.

Liu Y, Tewari R, Ning J, Blagborough AM, Garbom S, Pei J, Grishin NV, Steele RE, Sinden RE, Snell WJ, Billker O, Genes & development, 2008 Apr; 22 (8):1051-68

A ciliary timer for S-phase entry.

Snell WJ, Golemis EA, Nature reviews. Molecular cell biology, 2007 Sep;

The primary cilium: keeper of the key to cell division.

Pan J, Snell W, Cell, 2007 Jun; 129 (7):1255-7