Mark Siegelman, MD, PhD

Associate Professor
Pathology, Immunology
Graduate Program: Immunology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-4121
Office Fax: 214-648-4033

mark.siegelman@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

FellowshipStanford University Hospital (1990)
ResidencyStanford University Hospital (1988)
InternshipStanford University Hospital (1984)
Medical SchoolUT Southwestern Medical Center (1983)

Research Interests

Adhesion and extravasation
Autoimmunity and inflammation
Leukocyte trafficking
Regulatory T cells
T cell activation

Publications

Featured
Suppressor potency among regulatory T cells is discriminated by functionally active CD44

Firan, M., Dhillon, S., Estess, P. and Siegelman, M. H. , Blood , January 2006; (107):619-627

Featured
Functional activation of CD44 is a marker of autoimmune disease activity

Estess, P., DeGrendele, H.C., Pascual, V., and Siegelman, M.H. , J. Clin. Invest. , 1998; (102):1173-1182

Featured
Requirement for CD44 in activated T cell extravasation into an inflamed site

DeGrendele, H.C., Estess, P., and Siegelman, M.H. , Science , 1997; (278):672-675

Featured
The route of antigen entry determines the requirement for L-selectin during immune responses

Catalina, M.D., Carroll, M.C., Arizpe, H., Takashima, A., Estess, P., Siegelman, M.H. , J. Exp. Med. , 1996; (184):2341-2351

Featured
Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains

Siegelman, M.H., Van der Rijn, M. and Weissman, I.L. , Science , 1989; (243):1165

Suppressor potency among regulatory T cells is discriminated by functionally active CD44

Firan, M., Dhillon, S., Estess, P., Siegelman, M.H. , Blood , January 2006; (107):619-627

Bimolecular Complex between rolling and firm adhesion receptors required for cell arrest: CD44 association with VLA-4 in T cell extravasation

Nandi, A., Estess, P. and Siegelman, M. H , Immunity , April 2004; (20):455-465 (Editorial pp. 361-362)

Hyaluronan anchoring and regulation on the surface of vascular endothelial cells is mediated through the functionally active form of CD44

Nandi, A., Estess, P., and Siegelman, M.H. , J. Biol. Chem. , 2000; (275):14939-14948

The CD44 initiated pathway of activated T cell extravasation utilizes the integrin VLA-4 but not LFA-1 for firm adhesion

Siegelman, M.H., Stanescu, D., and Estess, P. , J. Clin Invest. , 2000; (105):683-691

Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E- and P- but not L-selectin

Catalina M.D., Estess, P., and Siegelman, M.H. , Blood , 1999; (93):580-589

Honors/Awards

Burroughs Wellcome Clinical Scientist Award in Translational Research

Grant award (1999)

McDonnell Scholars Award

Scholarship grant award (1990)

Bristol-Meyers Cancer Research Fellowship

Research fellowship (1988)

NIH Postdoctoral Fellowship

Research fellowship (1984)

Texas Merit Scholarship Award

Medical student financial award (1979)

Professional Associations/Affiliations

American Association of Immunology

American Society for Investigative Pathology

Association for Molecular Pathology