Jerry Shay, PhD

Professor
Endowed Title: Southland Financial Corporation Distinguished Chair in Geriatrics
Cell Biology
Graduate Program: Cancer Biology
Genetics and Development

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2570
Office Fax: 214-648-8694

jerry.shay@utsouthwestern.edu

Biography

Jerry W. Shay Professor

EDUCATION/TRAINING

 The University of Texas at Austin, BA, Zoology/ Cell Biology, 1966

The University of Kansas at Lawrence, MA, Cell Biol. & Physiol.Mol. Cell., 1968

The University of Colorado at Boulder, PhD, Develop. Biology, 1972-1975

 

POSITIONS AND EMPLOYMENT

1975-1993 Assistant/Associate Professor, Department of Cell Biology/Neuroscience, UT Southwestern

1993- Professor, Department of Cell Biology, UT Southwestern, Southland Financial Corporation Distinguished Chair in Geriatric Research

2002- Associate Director, Education and Training, UT Southwestern Harold Simmons Comprehensive Cancer Center

PANELS

1990-1994 Member, NIH Study Section on Mammalian Genetics

1995-1997 Susan G. Komen Breast Cancer Foundation Research Grant Committee

1996- present Mary Kay Ash Foundation, Chairman, Scientific Review Committee

1998-1999 Breast Cancer Research Program Integration Panel (ad hoc)

 

SCIENTIFIC ADVISORY BOARDS/CONSULTATIONS

1996-present External Advisory Committee - Univ. Calif. San Diego Cancer Center

2002- present Reata Pharmaceutical, Dallas, TX (SAB)

 

 

EDITORIAL BOARDS

In Vitro, Cellular and Developmental Biology; Methods in Cell Science; Differentiation; International Journal of Molecular Medicine and Oncology; Experimental Gerontology; Antiaging Research; Mechanisms of Aging and Development: Aging Research Reviews; J. Clinical Pathology; Neoplasia; Cancer Research; J. National Cancer Institute; Clinical Cancer Research; J. Regenerative Medicine.

 

AWARDS

1978-1983 NIH Research Career Development Award

1995-1997 AlliedSignal Award for Research on Aging

1997 Institute for Scientific Research - Most highly cited researchers

1996-2003 Ellison Medical Foundation Senior Scholar

2001 American Aging Association, Hayflick Award

2005-2008 Ted Nash Award

 

CURRENT INTERNAL COMMITTEES

1996- Senior Leadership Committee UT Southwestern Simmons Comprehensive Cancer Center

1997-present Executive Committee UTSW/MD Anderson Lung Cancer SPORE

2002- Search Committee, Chair in Radiation Oncology

2002- Search Committee, Director Simmons Comprehensive Cancer Center

2002- American Cancer Society Internal Review Committee

 

US PATENTS

#5,489,508 Issue date: 02/06/96

"Therapy and Diagnosis of Conditions Related to Telomere Length and/or Telomerase Activity"

 

#5,639,613 Issue data: 06/17/97

"Methods for Cancer Diagnosis and Prognosis"

 #5,645,986 Issue date: 07/08/97

"Telomerase Activity Inhibitor Screening"

 #5,648,215 Issue date: 07/15/97

"Telomerase Diagnostic Methods"

 #5,686,245 Issue date: 11/11/97

"Screening for Agents that Modulate Telomere Length"

 

#5,686,306 Issue date: 11/11/97

"Methods and Reagents for Lengthening Telomeres"

#5,693,474 Issue date: 12/2/97

"Methods for Cancer Diagnosis and Prognosis"

#5,695,932 Issue date: 12/9/97

"Telomerase Activity Assays for Diagnosing Pathogenic Infections and Identifying Pathogen Telomerase Inhibitors"

 

#5,707,795 Issue date: 1/13/98

"Diagnosis of Conditions Related to Telomere Length"

#5,830,644 Issue date: 11/3/98

"Method for Screening for Agents which Increase Telomerase Activity in a Cell"

Education

Graduate SchoolUniversity of Kansas Main Campus (1972)
Graduate SchoolUniversity of Texas at Austin (1968)

Research Interests

Cancer stem cells
Cell Biology of the cancer genome
Mechanisms of cellular immortalization
Mouse models of radiation-induced cancer
Role of telomeres and telomerase in cancer and aging

Publications

Featured
Telomere position effect in human cells.

Baur, J.A., Shay, J.W. and Wright, W.E. , Science , 2001; (292):2075-2077

Featured
Lack of cancer-associated changes in human fibroblasts after immortalization with telomerase.

Morales, C.P., Holt, S.E., Ouelette, M., Kaur, K.J., Wilson, K.S., White, M.A., Wright, W.E., and Shay, J.W, , Nature Genetics , 1999; (21):115-118

Featured
Extension of lifespan by introduction of telomerase in normal human cells.

Bodnar, A.G., Ouellete, M., Frolkis, M., Holt, S.E., Chiu, C.P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S., and Wright, W.E. , Science , 1998; (279):349-352

Featured
Correlating telomerase activity levels with human neuroblastoma outcomes.

Hiyama, E., Hiyama, K., Yokoyama, T., Matsuura, Y., Piatyszek, M.A., Shay, J.W. , Nature Medicine , 1995; (1):249-357

Featured
Specific association of human telomerase activity with immortal cells and cancer.

Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L.C., Coviello, G.M., Wright, W.E., Weinrich, S.L., Shay, J.W. , Science , 1994; (266):2011-2015

Resveratrol facilitates immortalization of epithelial prgenitor cells

Pearce, V.P. ... Shay, J.W. , Oncogene , Spring 2008; (27):2365-2374

Actions of human telomerase beyond telomeres

Y-S Cong, J.W. Shay , Cell Research , Spring 2008; (18):725-732

Anti-adhesive effects of GRN163L: an oligonucleotide, N3-P5 thio-phosphoramidate targeting telomerase.

Jackson, S.R, Zhu, C-H., Paulson,V., Watkin, L., Dikemen, Z.G., Gryaznov, S.M., Wright, W.E. and Shay, J.W. , Cancer Research , Spring 2007; (67):1121-1129

Adult-onset pulmonary fibrosis caused by mutations in telomerase

Tsakiri, K.D., Cronkite, J.T., Kuan, P.J. Xing, C., Ganesh, R., Weissler, J.C., Rosenblatt, R.L. Shay, J.W. Garcia, C.K , PNAS , Spring 2007; (104):7552-7557

Two and three dimensional models for risk assessment of radiation-enhanced colorectal turmorigenesis

Roig, A. I. , Hight, S.K., and Shay, J.W. , Radiation Research , Fall 2008; (in press)

Honors/Awards

Doctor of the Decade (1995-2005)

Ranked 6th Most Cited Author in General Biomedical Sicence (2006)

Ted Nash Award

Aging Research (2006)

Hayflick Award

American Aging Association (2001)

Southland Financial Corporation

Distinguished Chair in Geriatric Research (2001)

Ellison Medical Foundation

Senior Scholar Award (1999)