PROFESSIONAL EXPERIENCE

1980-1981 Massachusetts Institute of Technology, Department of Biology. Undergraduate student. Research: Regulation of E.coli alkaline phosphatase synthesis using an in vitro transcription-translation system.

1981-1986 University of California, Berkeley, Department of Molecular Biology. Graduate student. Research: Identification and purification of the e-subunit of E. coli DNA polymerase III: an editing exonuclease for DNA replication.

1986-1991 Basel Institute for Immunology, Basel, Switzerland. Research Member Research: Analysis of mouse immunoglobulin heavy chain enhancer regulation. Molecular aspects of hematopoiesis and tumorigenesis using c-myc transgenic mice.

1992-Present UT Southwestern Medical Center, Department of Pathology.

Assistant Professor (1992-1998); Associate Professor with tenure (1998-2004); Professor (2004-present).

Research: Signal transduction, cell cycle control and apoptosis in the regulation of tumor cell growth and dormancy in vivo and in vitro. The role of repression and nuclear matrix attachment in immunoglobulin heavy chain enhancer and TNF-alpha regulation and lymphoid development. Quantitative PCR as a diagnostic tool to evaluate human herpesvirus activation in immuno-compromised patients and to measure minimal residual disease in cancer patients. Signal transduction in the control of antigen processing and presentation in B lymphocytes. Bioinformatics and computational biology applied to problems in microbiology and immunology.

Jan. 2002 - Aug. 2002 University of California, San Diego, San Diego Supercomputer Center, Visiting Scholar (sabbatical). Research: Develop of a relational database to integrate results obtained from multiple experimental approaches, and to develop data analysis algorithms to provide a comprehensive understanding of the complexities of signal transduction at a whole-cell level.