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David Russell, PhD
Professor
Endowed Title: Eugene McDermott Distinguished Chair in Molecular Genetics
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-648-2141
Office Fax: 214-648-8804
Biography
David W. Russell received a BA degree in biology from UT Austin in 1975 and a PhD in chemistry from the University of North Carolina in 1980. He was a Damon Runyon Cancer Research Foundation postdoctoral fellow from 1980-1982 with Nobel laureate Dr. Michael Smith (Chemistry, 1993) at the University of British Columbia. He joined the faculty at UT Southwestern in 1982, was promoted to professor in 1990, and received the McDermott Distinguished Chair of Molecular Genetics in 1992.
Dr. Russell’s research interests are in lipid metabolism, in particular the enzymatic pathways that dispose of cholesterol. His laboratory has isolated over a dozen genes that encode enzymes involved in cholesterol breakdown, and has identified the molecular bases of six human genetic diseases characterized by abnormal cholesterol and lipid metabolism. Dr. Russell and Dr. Joseph Sambrook are the authors of the best selling molecular biology cloning manual, Molecular Cloning, published by Cold Spring Harbor Laboratory Press.
Dr. Russell is the recipient of a Research Career Development Award from the National Institutes of Health, the Katz Award from the American Heart Association, the Kilby Science Place Award from Texas Instruments, the Oppenheimer Award from the Endocrine Society, the Windaus Prize from the Falck Foundation, the Avanti Award in Lipids from the American Society for Biochemistry and Molecular Biology, the Barbara Bowman Distinguished Geneticist Award from the Texas Genetics Society. He was elected to the National Academy of Sciences in 2006 and the American Academy of Arts & Sciences in 2011.
Education
| Graduate School | University of North Carolina at Chapel Hill (1980) |
| Undergraduate | University of Texas at Austin (1975) |
Research Interests
Publications
Cheng, J.B., Levine, M.A., Bell, N.H., Mangelsdorf, D.J., and Russell, D.W. , Proc. Natl. Acad. Sci. USA. , 2004; (101):7711-7715
Schwarz, M., Wright, A.C., Davis, D.L., Nazer, H., Bjorkhem, I., and Russell, D.W. , J. Clin. Invest. , 2000; (106):1175-1184
Setchell, K.D.R., Schwarz, M., O'Connell, N.C., Lund, E.G., Davis, D.L., Lathe, R., Thompson, H.R., Tyson, R.W., Sokol, R.J., and Russell, D.W. , J. Clin. Invest. , 1998; (102):1690-1703
Thigpen, A.E., Davis, D.L., Milatovich, A., Mendonca, B.B., Imperato-McGinley, J., Griffin, J.E., Francke, U., Wilson, J.D., and Russell, D.W. , J. Clin. Invest. , 1992; (90):799-809
Cali, J.J., Hsieh, C-L., Francke, U., and Russell, D.W. , J. Biol. Chem. , 1991; (266):7779-7783
Bauman, D.R., Bitmansour, A.D., McDonald, J.G., Thompson, B.M., Liang, G., Russell, D.W. , Proc. Natl. Acad. Sci. USA , September 2009; (106):16764-9
Stiles, A.R., McDonald, J.G., Bauman, D.R., Russell, D.W. , J. Biol. Chem. , 2009; (284):28485-9
Russell, D.W., Halford, R.W., Ramirez, D.M., Shah, R., Kotti, T. , Annu. Rev. Biochem. , 2009; (78):1017-40
Shea, H.C., Head, D.D., Setchell, K.D.R., and Russell, D.W. , Proc. Natl. Acad. Sci. USA , 2007; (104):11526-11533
Chen, W., Chen, G., Head, D.L., Mangelsdorf, D.J., Russell, D.W. , Cell Metabolism , 2007; (5):73-9
Related Links
Honors/Awards
(2006)
(2002)
(1999)
(1993)
(1985)