Elliott Ross, PhD

Professor
Endowed Title: Greer Garson and E.E. Fogelson Distinguished Chair in Medical Research
Pharmacology
Graduate Program: Cell Regulation
Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6134
Office Fax: 214-645-6138

elliott.ross@utsouthwestern.edu

Biography

Dr. Ross’s research focuses on how cells receive, amplify, integrate, and sort information. The work focuses on the integrated control of cellular signaling pathways, particularly those that involve GTP-binding proteins.

Education

Graduate SchoolCornell University (1975)
UndergraduateUniversity of California-Davis (1970)

Research Interests

Computational modeling of signaling networks
Integration of biological signaling
Interaction of membrane-bound enzymes and hormone receptors
Mechanisms of G protein-mediated signal transduction
Structure of G protein-coupled receptors

Publications

Featured
RGSZ1, A Gz-Selective RGS Protein in Brain: Structure, Membrane Association, Regulation by Gαz Phosphorylation, and Relationship to a Gz GTPase-Activating Protein Subfamily

Wang, J., Ducret, A., Tu, Y., Kozasa, T, Aebersold, R., and Ross, E.M. , J. Biol. Chem. , October 1998; (273):26014-26025

Featured
Inhibition of Brain Gz GAP and Other RGS Proteins by Palmitoylation of Protein α Subunits

Tu, Y., Wang, J., and Ross, E.M. , Science , November 1997; (278):1132-1135

Featured
Coordinate Regulation of G Protein Signaling via Dynamic Interactions of Receptor and GAP

Turcotte, M., Tang, W., Ross, E.M. , PLoS Computational Biology , August 2008; (4):e100148

Featured
Rapid GTP binding and hydrolysis by Gq promoted by receptor and GTPase-activating proteins

Mukhopadhyay, S., and Ross, E.M. , Proc. Natl. Acad. Sci. USA , August 1999; (96):9539-9544

Featured
Phospholipase C-β1 is a GTPase Activating Protein for Gq/11, its Physiologic Regulator

Berstein, G., Blank, J.L., Jhon, D-Y., Exton, J.H., Rhee, S.G., and Ross, E.M. , Cell , August 1992; (70):411-418

Featured
Regulation of Phospholipase C-β1 by Gq and m1 Muscarinic Cholinergic Receptor: Steady-State Balance of Receptor-Mediated Activation and GAP-Promoted Deactition

Biddlecome, G.H., Berstein,G., and Ross, E.M. , J. Biol. Chem. , April 1996; (271):7999-8007

Featured
Synergistic activation of phospholipase C-beta3 by Galpha(q) and Gbetagamma describes a simple two-state coincidence detector.

Philip F, Kadamur G, Silos RG, Woodson J, Ross EM, Current biology : CB, 2010 Aug; 20 (15):1327-35

Featured
Coordinating speed and amplitude in G-protein signaling.

Ross EM, Current biology : CB, 2008 Sep; 18 (17):R777-R783

Featured
GTPase-activating Proteins (GAPs) For Heterotrimeric G Proteins: Regulators Of G Protein Signaling (RGS) And RGS-like Proteins

Ross, E.M., and Wilkie, T.M. , Annu. Rev. Biochem. , 2000; (96):795-827

Uncoupling Conformational Change From GTP Hydrolysis In A Heterotrimeric G Protein alpha Subunit. Proc.

Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R. , Proc.Natl. Acad. Sci. , March 2004; (101):7560-7565

Honors/Awards

NIGMS MERIT Award

(2002)

ASPET Goodman and Gilman Award for Drug-Receptor Pharmacology

(1996)

Chairman, Gordon Research Conference on Molecular Pharmacology

(1991)

Scientific Director, NATO/FEBS Adv. Study Inst. on Biological Signal Transduction

(1990)

Professional Associations/Affiliations

American Society for Biochemistry and Molecular Biology

American Society for Pharmacology and Experimental Therapeutics (Section on Molecular Pharmacology)

Biophysical Society