Susanne Mumby, PhD

Assistant Dean
Associate Professor
Pharmacology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-633-1323
Office Fax: 214-648-4150

susanne.mumby@utsouthwestern.edu

Education

Graduate SchoolUniversity of Washington (1984)
UndergraduateUniversity of California-Riverside (1975)

Research Interests

G Protein-Mediated Cell Signaling
Structure and Function of Lipid Modificiations of Proteins

Publications

Featured
Persistent membrane association of activated and depalmitoylated G protein alpha subunits

Huang, C., Duncan, J.A., Gilman, A.G., and Mumby, S.M. , Proc. Nat'l. Acad. Sci. USA , 1999; (96):412-417

Featured
Attenuation of Gi-andGq-mediated signaling by expression of RGS4 or GAIP in mammalian cells

Huang, C., Hepler, J.R., Gilman, A.G., and Mumby, S.M. , Proc. Nat'l. Acad. Sci. USA , 1997; (94):6159-6163

Featured
Organization of G proteins and adenylyl cyclase at the plasma membrane

Huang, C., Hepler, J.R., Chen, L.T., Gilman, A.G., Anderson, R.G.W., and Mumby, S.M. , Mol. Bio. Cell , 1997; (8):2365-2378

Featured
Lipid modifications of G proteins: alpha subunits are palmitoylated

Linder, M.E., Middleton, P., Hepler, J.R., Taussig, R., Gilman, A.G., and Mumby, S.M. , Proc. Nat'l. Acad. Sci. USA , 1993; (90):3675-3679

Featured
G protein gamma subunits contain a twenty-carbon isoprenoid

Mumby, S.M., Casey, P.J., Gilman, A.G., Gutowski, S., and Sternweis, P.C. , Proc. Nat'l. Acad. Sci. USA , 1990; (87):5873-5877

Differentially Regulated Expression of Endogenous RGS4 and RGS7.

Krumins, A.M. Barker, S.A., Huang, C., Sunahara, R.K., Yu, K., Wilkie, T.M., Gold, S.J., Mumby, S.M. , J. Biol. Chem. , 2004; (279):2593-2599

Gs Family of Heterotrimeric G. Proteins

Mumby, S.M. , Encyclopedia of Biological Chemistry , 2004; (Vol. 2):337-342

Introduction to the AfCS Antibody Database: Tabulation of Our Experience with Commercially Available Antibodies

Han H, Fulin B, Sorrells L, Levitz R, Sinkovits R, and Mumby S , AfCS Research Reports , 2003; (1(7):doi:10.1038/afcs.da0)

Subcellular Localization of G Protein Subunits

Mumby, S.M. , Meth. Enzyol. , 2002; (344):383-403

Plasma membrane estrogen receptors are coupled to eNOS through G alpha i

Wyckoff, M.H., Chambliss, K.L., Mineo, C., Yahanna, I.S., Mendelsohn, M.E., Mumby, S.M., and Shaul, P.W. , J. Biol. Chem , 2001; (276):27071-27076

Professional Associations/Affiliations

American Association for Advancement of Science

American Society for Biochemistry and Molecular Biology

American Society for Pharmacology and Experimental Therapeutics