Marc Mumby, PhD

Professor
Pharmacology
Graduate Program: Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6152
Office Fax: 214-645-6131

marc.mumby@utsouthwestern.edu

Education

Graduate SchoolUniversity of California-Berkeley (1978)
UndergraduateUniversity of California-Berkeley (1973)

Research Interests

Cellular Signal Transduction
Nutrient signaling
Protein Phosphatases
Protein Phosphorylation
Proteomics

Publications

Featured
The actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

Silverstein AM, Barrow CA, Davis AJ, Mumby MC , Proc. Nat. Acad. Sci. USA , 2002; (99):4221-4226

Featured
PR48, a novel regulatory subunit of PP2A, interacts with Cdc6 and modulates DNA replication in human cells

Yan Z, Fedorov SA, Mumby MC, Williams RS , Mol Cell Biol , 2000; (20):1021-1029

Featured
Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation

Yan Y, Shay JW, Wright W, Mumby MC , J Biol Chem , 1997; (272):15220-15226

Featured
Regulation of the phosphorylation state and microtubule-binding activity of tau by protein phosphatase 2A

Sontag E, Nunbhakdi-Craig V, Brandt R, Lee G, Bloom GS, Mumby MC , Neuron , 1996; (17):1201-1207

Featured
The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the MAP kinase pathway and induces cell proliferation

Sontag E, Federov S, Kamibayashi C, Robbins D, Cobb M, Mumby M , Cell , 1993; (75):887-897

The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling

Mumby, M. , ACS Chemical Biology , 2007; (2):99-103

A functional genomics analysis of the B56-isoforms of Drosophila protein phosphatase 2A

Liu W, Silverstein AM, Shu H, Martinez B, Mumby MC. , Mol Cell Proteomics , 2007; (6):319-332

PP2A: Unveiling a reluctant tumor suppressor

Mumby, M. , Cell , 2007; (130):21-24

Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase

Bielinski, V.A. and Mumby, M.C. , Exp Cell Research , 2007; (313):3117-3129

PP2A is required for centromeric localization of Sgo1 and proper chromosomes segregation

Tang Z, Shu H, Qi W, Mahmood N, Mumby MC, Yu H. , Developmental Cell , 2006; (10):575-585

Honors/Awards

The Rosa Lowie Award

Catholic University of Leuven, Belgium (1987)

Established Investigator

American Heart Association (1986)

Juvenile Diabetes Foundation Postdoc Fellowship

Juvenile Diabetes Foundation (1982)

Postdoctoral National Research Service Award

National Institutes of Health (1980)

Chancellor's Patent Fund Award

University of California Riverside (1977)

Professional Associations/Affiliations

Associate Editor, Molecular Biology of the Cell

Chairman, FASEB Conference on Protein Phosphatase

Chairman, NIH Biochemistry Study Section

Director, Protein Chemistry Laboratory, The Alliance for Cellular Signaling

Editorial Board, Journal of Biological Chemistry