Orson Moe, MD

Professor
Endowed Title: Charles Pak Distinguished Chair in Mineral Metabolism
Donald W. Seldin Professorship in Clinical Investigation
Internal Medicine, Physiology
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

orson.moe@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Orson Moe received his medical degree from the University of Toronto and is currently Professor of Internal Medicine and Physiology at the University of Texas Southwestern Medical Center. He is the Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research. He is also a member of the Nephrology Division at Southwestern. Dr. Moe is the holder of the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. In addition to editing Current Opinions of Nephrology and Hypertension, Dr. Moe also serves on the editorial board of the American Journal of Physiology, Journal of the American Society of Nephrology, and Initial Review Group at the National Institutes of Health Center for Scientific Review. Dr. Moe is currently a member of the American Society of Clinical Research, American Association of Physicians, American Society of Nephrology, American Physiologic Society, and Biophysical Society.

Education

FellowshipUT Southwestern Medical Center at Dallas, Nephrology (1990)
FellowshipSt. Michael's Hospital, Nephrology (1987)
ResidencySt. Michael's Hospital, Internal Medicine (1986)
InternshipSt. Michael's Hospital, Medical/Surgical (1983)
Medical SchoolUniversity of Toronto Faculty of Medicine (1982)

Research Interests

Epithelial Biology
Ion Transport
Metabolism

Publications

Featured
Steady-state function of the ubiquitous mammalian Na/H exchanger (NHE1) in relation to dimer coupling models with 2Na/2H stoichiometry

Fuster D, Moe OW, Hilgemann DW , J Gen Physiol , October 2008; (132):465-80

Featured
Synergistic upregulation of erythropoietin receptor (EPO-R) expression by sense and antisense EPO-R transcripts in the canine lung

Zhang Q, Zhang J, Moe OW, Hsia CC , Proc Natl Acad Sci USA , May 2008; (105):7612-7617

Featured
Comparison of semi-empirical and computer derived methods for estimating urinary saturation of brushite

Pak CY, Moe OW, Maalouf N, Zerwekh JE, Poindexter JR, Adams-Huet B, Rodgers K. , J Urol , March 2009; (181):1423-8

Featured
Mechanism of urinary calcium regulation by urinary magnesium and pH

Bonny O, Rubin A, Huang C-L, Frawley WH, Pak CYC, Moe OW , J Am Soc Nephrology , April 2008; (Epub ahead of print)

Posing the question again: Does chronic uric acid nephropothy exist? (Commentary)

Moe OW , American Society of Nephrology , September 2010; (21):395-397

Klotho deficiency causes vascular calcificiation in chronic kidney disease

Hu MC, Shi, M, Zhang J, Quinones H, Griffith C, Kuro-o M, Moe OW , J Am Soc Nephrology , January 2011; (22):124-36

Nephrolithiasis-associated bone disease: pathogenesis and treatment options

Sakhaee K, Maalouf N, Pasch A, Kumar R, Moe OW , Kidney International , February 2011; (79):393-402

Acute regulation of renal Na+/H+ exchanger NHE3 by dopamine: Role of protein phosphatase 2A

Bobulescu IA, Qui?ones H, Gisler SM, Di Sole F, Shi M, Hu MC, Zhang J, Fuster DG, Wright N, Mumby M, Moe OW , American Journal of Physiology , February 2010; (298):F1205-1213

Metabolic basis for low urine pH in type 2 diabetes mellitus

Maalouf N, Cameron MA, Moe OW, Sakhaee K , Clin J Am Soc Nephrology , April 2010; (5):1277-81

Honors/Awards

Outstanding Freshman Teacher

1st yr medical students (2011)

Outstanding Freshman Teacher

1st yr medical students (2006)

National Kidney Foundation of Canada

Recipient of Research Fellowship (1987)

Professional Associations/Affiliations

Fellow, Royal College of Physicians of Canada

Member, American Physiologic Society

Member, American Society of Clinical Investigation

Member, American Society of Nephrology

Member, National Kidney Foundation