Chieko Mineo, PhD

Assistant Professor
Pediatrics
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

chieko.mineo@utsouthwestern.edu

Education

Graduate SchoolUniversity of Tokyo - Japan, Pharmacology (1992)
UndergraduateUniversity of Tokyo - Japan, Pharmacology (1982)

Research Interests

Antiphospholipid Syndrome
Vascular Biology and Atherosclerosis

Publications

PON-dering differences in HDL function in coronary artery disease.

Mineo C, Shaul PW, The Journal of clinical investigation, 2011 Jul; 121 (7):2545-8

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via ß2GPI and apoER2.

Ramesh S, Morrell CN, Tarango C, Thomas GD, Yuhanna IS, Girardi G, Herz J, Urbanus RT, de Groot PG, Thorpe PE, Salmon JE, Shaul PW, Mineo C, The Journal of clinical investigation, 2011 Jan; 121 (1):120-31

The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity

Zhu W, Saddar S, Seetharam D, Chambliss KL, Longoria C, Silver DL, Yuhanna IS, Shaul PW, Mineo C. , Circulation Research , February 2008; (102(4)):480-487

HDL Promotes Endothelial Cell Migration via SR-BI-mediated Kinase Activation

Seetharam D, Mineo C, Gormley AK, Vgpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW , Circulation Research , 2006; (98):63-72

FCgRIIB Mediates C-Reactive Protein Inhibition of Endothelial NO Synthase FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase

Mineo C, Gormley AK, Yuhanna IS, Osborne-Lawrence S, Gibson LL, Hahner L, Shohet RV, Black S, Salmon JE, Samols D, Karp DR, Thomas GD, Shaul PW , Circulation Research , 2005; (97):1124-1131

Cholesterol Binding, Efflux and a PDZ-interacting Domain of SR-BI mediate HDL-Initiated Signaling.

Assanasen C*, Mineo C*, Seetharam D, Yuhanna IS, Marcel YL, Connelly MA, Willams DL, de la Llera-Moya M, Shaul PW, Silver DL(*shared leading authorship) , Journal of Clinical Investigation , 2005; (115):969-977

High Density Lipoprotein-induced Endothelial Nitric-oxide Synthase Activation Is Mediated by Akt and MAP Kinases.

Mineo C, Yuhanna IS, Quon MJ and Shaul PW. , J. Biol. Chem. , 2003; (278):9142-9149

Regulated migration of EGF receptor from caveolae.

Mineo C, Gill GN, and Anderson RGW. , J. Biol. Chem. , Select Month or Season 1999; (274):30636-30643

Targeting of protein kinase Ca to caveolae.

Mineo C, Ying YS, Chapline C, Jaken S, and Anderson RGW. , J. Cell Biol. , Select Month or Season 1998; (141 (3)):601-610

High Density Lipoprotein-induced Endothelial Nitric-oxide Synthase Activation Is Mediated by Akt and MAP Kinases.

Mineo C, Yuhanna IS, Quon MJ and Shaul PW. , J. Biol. Chem. , Select Month or Season; ((In press))

Honors/Awards

American Heart Association

Scientist Development Program (PI, 2002-2006)