Peter Michaely, PhD

Assistant Professor
Cell Biology
Graduate Program: Biological Chemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2570
Office Fax: 214-648-8694

peter.michaely@utsouthwestern.edu

Biography

Education:
The University of Illinois (Champaign-Urbana)
BS, Biochemistry
BS, Genetics and Development
8/1984 - 5/1989

Duke University (Durham, NC)
PhD, Biochemistry
Vann Bennett, mentor
8/1989-5/1995

Post-Graduate Positions:
Postdoctoral Fellow, Dr. Vann Bennett, PI
Duke University (Durham, NC) 5/1995-2/1996

Postdoctoral Fellow, Dr. Richard Anderson, PI
UT Southwestern
2/1996-8/2002

Instructor, Department of Cell Biology
UT Southwestern
8/2002-8/2005

Assistant Professor, Department of Cell Biology
UT Southwestern
8/2005-present

Education

Graduate SchoolDuke University, Biochemistry (1995)
UndergraduateUniversity of Illinois Central Office, Biochemistry (1989)

Research Interests

Choleolerol homeostasis - LDLR mediated lipoprotein uptake
Protein structure - proteins containing repeating amino acid motifs

Publications

Featured
Nanospring behaviour of ankyrin repeats

Lee G, Abdi K, Jiang Y, Michaely P, Bennett V, Marszalek PE , Nature , March 2006; (440):246-9

Featured
Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR

Michaely P, Zhao Z, Li WP, Garuti R, Huang LJ, Hobbs HH, Cohen JC , EMBO J. , July 2007; (26):3273-82

Featured
Crystal structure of a 12 ANK repeat stack from human ankyrinR

Michaely P, Tomchick DR, Machius M, Anderson RG , EMBO J. , December 2002; (21):6387-96

Featured
Localization and structure of the ankyrin-binding site on beta 2-spectrin

Davis L, Abdi K, Machius M, Brautigam C, Tomchick DR, Bennett V, Michaely P , J. Biol. Chem. , 2009; (284):6982-7

Featured
The EGF-homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562 and H586

Zhao Z, Michaely P , J. Biol. Chem. , 2008; (283):26528-37

Nanospring behaviour of ankyrin repeats

Lee G, Abdi K, Jiang Y, Michaely P, Bennett V, Marszalek PE , Nature , March 2006; (440):246-9

Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR

Michaely P, Zhao Z, Li WP, Garuti R, Huang LJ, Hobbs HH, Cohen JC , EMBO J. , July 2007; (26):3273

Localization and structure of the ankyrin-binding site on beta 2-spectrin

Davis L, Abdi K, Machius M, Brautigam C, Tomchick DR, Bennett V, Michaely P , J. Biol. Chem. , 2009; (284):6982-7

The Role of Calcium in Lipoprotein Release by the Low-Density Lipoprotein Receptor

Zhao Z, Michaely P , Biochemistry , 2009; (48):7313-24

The EGF-homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562 and H586

Zhao Z, Michaely P , J. Biol. Chem. , 2008; (283):26528-37