Carole Mendelson, PhD

Professor
Biochemistry, Obstetrics & Gynecology
Graduate Program: Biological Chemistry
Cell Regulation
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

carole.mendelson@utsouthwestern.edu

Biography

Carole Mendelson received a B.S. in Biology from the City College of New York and a Ph.D. in Zoology from Rutgers University, New Brunswick, N.J. She spent five years as a postdoctoral and then Staff Fellow at the National Institutes of Health in Bethesda, Maryland. She joined the faculty of UT Southwestern in 1978. Research in the Mendelson laboratory is focused on reproductive and perinatal biology and includes: (1) genetic and epigenetic mechanisms in the developmental, hormonal and tissue-specific regulation of the gene encoding SP-A, the major protein of pulmonary surfactant; (2) transcriptional regulation of aromatase (CYP19) gene expression in estrogen-producing tissues and in pathologic states, including endometriosis, cancer and preeclampsia; (3) regulatory mechanisms involved in maintenance of uterine quiescence during pregnancy and activation of contractile genes leading to term and pre-term labor. Dr. Mendelson’s research is funded by the National Institutes of Health and March of Dimes Foundation. She held an NIH MERIT Award from 1998 – 2008.

Dr. Mendelson served as a member of the Board of Scientific Counselors for the National Heart, Lung and Blood Institute, NIH, and currently chairs the Reproductive Scientist Development Program Selection Committee and is a member of the Basil O’Connor Starter Scholar Research Award Advisory Committee. She is active within The Endocrine Society (TES), in which she has chaired a number of committees and served as a member of Council and as Vice President for Basic Scientists from 2008 – 2011. She also has been active in several committees that support the career advancement of women in science and medicine. She was president of Women in Endocrinology of TES. Within UT Southwestern, she co-chairs the Women in Science and Medicine Advisory Committee and chairs the Committee on the Advancement of Women.

Education

Graduate SchoolRutgers University New Brunswick, Zoology (1970)
UndergraduateCity College of New York, Biology (1964)

Research Interests

Mechanisms in the initiation of parturition
Molecular Mechanisms in the developmental, hormonal and tissue-specific regulation of surfactant protein gene expression in fetal lung tissue
Molecular mechanisms in the regulation of aromatase in estrogen-producing cells

Publications

Featured
miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor.

Renthal NE, Chen CC, Williams KC, Gerard RD, Prange-Kiel J, Mendelson CR, Proceedings of the National Academy of Sciences of the United States of America, 2010 Nov; 107 (48):20828-33

Featured
Expression of surfactant protein by the fetal lung signals the initiation of labor

Condon JC, Pancharatnam J, Faust JM, Mendelson CR , Proc Natl Acad Sci USA , 2004; (101):4978-4983

Featured
Potential role of nuclear factor kB and reactive oxygen species (ROS) in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells

Islam K, Mendelson CR , Mol Endocrinol , 2002; (16):1428-1440

Featured
Regulation of the synthesis of the major surfactant apoprotein in fetal rabbit lung tissue

Mendelson CR, Chen C, Boggaram V, Zacharias C, Snyder JM , J Biol Chem , 1986; (261):9938-9943

Featured
Isolation and characterization of a complementary DNA specific for human aromatase cytochrome P-450 mRNA

Evans CT, Ledesma DB, Schulz TZ, Simpson ER, Mendelson CR , Proc Natl Acad Sci USA , 1986; (83):6387-6391

Progesterone Receptor Inhibits Proliferation of Human Breast Cancer Cells via Induction of MAPK Phosphatase 1 (MKP-1/DUSP1).

Chen CC, Hardy DB, Mendelson CR, The Journal of biological chemistry, 2011 Dec; 286 (50):43091-102

Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress.

Maitra M, Wang Y, Gerard RD, Mendelson CR, Garcia CK, The Journal of biological chemistry, 2010 Jul; 285 (29):22103-13

Honors/Awards

Mentor Award

Women in Endocrinology (2010)

Vice-President, Basic Science

The Endocrine Society (2008)

Alpha Omega Alpha

Honor Society (2002)

Roy O. Greep Award

The Endocrine Society (2001)

NIH MERIT Award

Regulation of SP-A Expression in Fetal Lung (1998)