Christopher Lu, MD

Professor
Internal Medicine
Graduate Program: Immunology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

christopher.lu@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

FellowshipHarvard Medical School, Nephrology (1981)
FellowshipHarvard Medical School, Pathology, Neurology (1980)
ResidencyBronx Municipal Hospital Center, Medicine (1977)
InternshipBronx Municipal Hospital Center, Medicine (1975)
Medical SchoolHarvard Medical School (1974)

Research Interests

acute kidney injury (acute renal failure)
perinatal infections
transplant rejection

Publications

Featured
The inflammatory response to ischemic acute kidney injury: a result of the ?right stuff? in the ?wrong place.?

Lu, C.Y., J Hartono, M. Senitko, J. Chen. , Current Opinion in Nephrology & Hypertension , 2007; (16 (2)):72-89

Featured
Injury from transplant surgery recruits recipient MHC Class II-positive leukocytes, including dendritic cells, into the transplanted kidney in a rat model where there is no rejection.

Penfield, J.G., Y.Wang, S. Li, M.A. Kielar, S.C. Sicher, D.R. Jeyarajah, and Lu, C.Y. , Kidney International , 1999; (56):1759-1769

Featured
Perspectives in basic science: Hypothesis: is renal allograft rejection initiated by the response to injury sustained during the transplant process?

Lu, C.Y., Penfield, J.G., Kielar, M.L., Vazquez, M.A., Jeyarajah, D.R , Kidney International , 1999; (55):2157-2168

Featured
The role of local immunosuppression in murine fetoplacental listeriosis.

Redline, R.W. and Lu, C.Y. , J. Clin. Invest. , 1987; (79):1234-1241

Featured
A defect in the antigen-presenting function of macrophages from neonatal mice.

Lu, C.Y., Calamai, E.G. and Unanue, E.R. , Nature , 1979; (282):327-329

An early proinflammatory signal in ischemic AKI is expression of interferon-regulatory-factor-1 by proximal tubules

Wang, Y. ......Lu, C. Y. , J Am Soc Nephrol , July 2009; (20):1544-55

Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury.

Chen J, John R, Richardson J, Shelton JM, Zhou X, Wang Y, Wu Q, Hartono J, Winterberg P, Lu CY. , Kidney International , January 2011; (79):288-299

Bardoxolone Methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes - Nrf2, PPAR gamma, and HO-1.

Wu Q, Wang Y, Senitko M, Meyer C, Wigley WC, Ferguson DA, Grossman E, Chen J, Zhou XJ, Hartono J, Winterberg P, Chen B, Agarwal A, Lu CY. , Am J Physiol (Renal Physiol) , 2011; (in press)

The maladaptive role of interleukin 6 in ischemic acute renal failure.

Kielar, M.L.; John, R.; Bennett, M.; Richardson,J.A.; Shelton, J.M.; Chen, L.; Jeyarajah, D.R.; Zhous, X.J.; Zhou, H.; Chiquett, B.; Nagami, G.T.; Lu, C. Y. , J. Am. Soc. Nephrol. , 2005; (16):3315-3325

Ischemia/ reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitro.

Zhang, Y., Woodward, V. K., Shelton, J. M., Richardson, J. A., Link, D. C., Zhou, X. J., Kielar, M. L., Jeyarajah, D. R. and Lu, C. Y. , Am J. Physiol - Renal Physiology , 2004; (286):F1193-201

Honors/Awards

President

Texas Transplantation Society (2008)

Permanent Member

NIH Pathobiol Kidney Dis Initial Rev Grp (2006)

Chairman

Kidney/ Pancreas Committee, Am Soc Transplant Phys (1996)

NIH Research Career Devel Award

(1989)

Phi Beta Kappa

(1969)

Professional Associations/Affiliations

American Association of Immunologists

American Society of Nephrology

American Society of Transplantation