Mark Lehrman, PhD

Professor
Pharmacology
Graduate Program: Biological Chemistry
Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6172
Office Fax: 214-645-6131

mark.lehrman@utsouthwestern.edu

Biography

Mark A. Lehrman received his BS in Biochemistry from the State University of New York at Stony Brook in 1977, and his PhD degree in Biochemistry from Duke University Medical Center in 1982. He is currently Professor of Pharmacology at UT Southwestern. His areas of research involve the structures, biosynthesis, functions, and disorders of mammalian glycoconjugates. He has served on the editorial boards of The Journal Of Biological Chemistry and of Glycobiology, was a member of the Pathobiochemistry Study Section (Center For Scientific Review, National Institutes Of Health), and is currently an Associate Editor for the journal Glycobiology.

Education

Graduate SchoolDuke University (1982)
UndergraduateSUNY at Stony Brook (1977)

Research Interests

Endoplasmic Reticulum Stress Responses - Unfolded Protein Response
Glycoconjugates of the Mammalian Endoplasmic Reticulum
N-linked Glycosylation and the Dolichol Pathway
Rare Metabolic Diseases Involving Sugar Abnormalities
Unconventional Glycogen Metabolism

Publications

Featured
Mannose-6-Phosphate Regulates Destruction Of Lipid-Linked Oligosaccharides.

Gao N, Shang J, Huynh D, Manthati VL, Arias C, Harding HP, Kaufman RJ, Mohr I, Ron D, Falck JR, Lehrman MA, Molecular biology of the cell, 2011 Jul; :2994-3009

Featured
Translational Balancing By The eIF2alpha Kinase PERK Couples ER Glycoprotein Synthesis To Lipid-linked Oligosaccharide Flux

Shang, J., Gao, N. Kaufman, R. J., Ron, D., Harding, H.P., and Lehrman, M.A. , Journal of Cell Biology , 2007; (176):605-616

Featured
Analysis Of Glycosylation In CDG-Ia Fibroblasts By Fluorophore-Assisted Carbohydrate Electrophoresis: Implications For Extracellular Glucose And Intracellular Mannose-6-Phosphate

Gao, N., Shang, J., and Lehrman, M. A. , The Journal Of Biological Chemistry , 2005; (280):17901-17909

Featured
Regulation Of The Dolichol Pathway In Human Fibroblasts By The Endoplasmic Reticulum Unfolded Protein Response.

Doerrler, W. T. and Lehrman, M. A. , Proc. Natl. Acad Sci. USA , 1999; (96):13050-13055 (Track II)

Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR)

Shang, J. and Lehrman, M.A. , Journal of Biological Chemistry , March 2004; (Vol. 279):12076-12080

Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation.

Harrison KD, Park EJ, Gao N, Kuo A, Rush JS, Waechter CJ, Lehrman MA, Sessa WC, The EMBO journal, 2011 ; 30 (12):2490-500

Antiangiogenic activity of 2-deoxy-D-glucose.

Merchan JR, Kovács K, Railsback JW, Kurtoglu M, Jing Y, Piña Y, Gao N, Murray TG, Lehrman MA, Lampidis TJ, PloS one, 2010 ; 5 (10):e13699

Teaching dolichol-linked oligosaccharides more tricks with alternatives to metabolic radiolabeling.

Lehrman MA, Glycobiology, 2007 Aug; 17 (8):75R-85R

Expression Cloning Of A Novel Suppressor Of The Lec15 and Lec35 Glycosylation Mutations Of Chinese Hamster Ovary Cells.

Ware, F.E. and Lehrman, M. A. , Journal of Biological Chemisty , 1996; (271):13935-13938

The Molecular Chaperone Calnexin Binds Glc1Man9GlcNAc2 Oligosaccharide As An Initial Step In Recognizing Unfolded Glycoproteins.

Ware, F.E., Vassilakos, A., Jackson, M., Lehrman, M.A. and Williams, D.B. , Journal of Biological Chemisty , 1995; (270):4697-4704

Honors/Awards

Jane Coffin Childs Memorial Fund

Research Fellowship, 1984 - 1985

National Institutes of Health

Postdoctoral Fellowship, 1983

Regents College Scholarship

1973 - 1977

Searle Scholars Program

1987 - 1990

Professional Associations/Affiliations

Associate Editor, Glycobiology (2004-2011)

Editorial Board, Journal of Biological Chemistry (1994-1998, 2012-2016)

President, Society For Glycobiology (2008)

Reviewer, Pathobiochemistry Study Section, NIH (1996-2000)