David Karp, MD, PhD

Professor
Endowed Title: Harold C. Simmons Chair in Arthritis Research
Internal Medicine
Graduate Program: Immunology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

david.karp@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Karp was raised near Cleveland, OH. He obtained his bachelor's degrees from the Massachusetts Institute of Technology and his medical and doctoral degrees from Washington University in St. Louis. He also completed his residency and clinical fellowship training at Barnes-Jewish Hospital in St. Louis before joining the NIH as a research fellow. He has been on the faculty of UT Southwestern since 1991. Dr. Karp's research has focused on the control of lymphocyte activation. He has studied the role of plasma proteins, termed complement, in the stimulation of B lymphocytes. This pathway is important in the protection of individuals from bacterial infection, and preventing autoimmune diseases such as systemic lupus erythematosus. Dr. Karp has also studied the effects of oxidative stress, a by-product of inflammation, tobacco smoke, and air pollution, on the immune system. Dr. Karp is Chief of the Rheumatic Diseases Division within the Department of Internal Medicine and directs clinical research in rheumatoid arthritis, osteoarthritis, and systemic lupus erythematosus.

Education

FellowshipWashington University Barnes Hospital, Rheumatology (1987)
ResidencyWashington University Barnes Hospital, Internal Medicine (1986)
InternshipWashington University Barnes Hospital, Internal Medicine (1985)
Medical SchoolBJC Healthcare (1984)

Research Interests

Ability of the complement system to regulate immune responses
Development of Data Sharing Methods in Biology
Genetics of human autoimmune diseases
Role of oxidative stress in the regulation of immunity

Publications

Featured
γ-Glutamyl transpeptidase activity alters the T cell response to oxidative stress and Fas-induced apoptosis

M.L. Carlisle, M. R. Wilkins, and D.R. Karp , Int Immunol , 2003; (15):17-27

Featured
Gamma glutamyl transpeptidase is upregulated on memory T lymphocytes

Karp, D. R., M. L. Carlisle, A. B. Mobley, T. C. Nichols, N. Oppenheimer-Marks, R. I. Brezinschek and V. M. Holers , International Immunology , 1999; (11):1791-1800

Featured
Complement opsonization is required for presentation of immune complexes by resting peripheral blood B cells

Susan A. Boackle, Margaret A. Morris, V. Michael Holers and David R. Karp , J. Immunol, , ; (161):6537-6543

Featured
CD21 augments antigen presentation in immune individuals

Susan A. Boackle, V. Michael Holers, and David R. Karp , Eur. J. Immunol. , ; (27):122-129

Featured
Complement receptors CD21/CD35 link innate and protective immunity during Streptococcul pneumoniae infection by regulating IgG3 antibody responses

K.M. Haas, M. Hasegawa, D.A. Steeber, J.C. Poe, M.D. Zabel, C.B. Bock, D. Karp, D.E. Briles, J.H. Weis, and T.F. Tedder , Immunity , ; (17):713-724

Protein array profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes

Quan-Zhen Li, Jinchun Zhou, Amy Wandstrat, Ferdicia Carr-Johnson, Valerie Branch, David Karp, Chandra Mohan, Edward Wakeland, and Nancy Olsen , Clin Exp Immunol , 2007; (147):60-70

Profiling populations at risk for systemic lupus erythematosus

A.E. Wandstrat, F. Carr-Johnson, V. Branch, H. Gray, A.-M. Fairhurst, A. Reimold, D. Karp, E.K. Wakeland, and N.J. Olsen , J. Autoimmunity , 2006; (27):153-160

Oxidative stress promotes polarization of human T cell differentiation towards a T helper 2 phenotype

M.R. King, A.S. Ismail, L.S. Davis, and D.R. Karp , J. Immunol , 2006; (176):2765-2772

Complement component C3d-Ag complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement

Y. Lee, K.M. Haas, D.O. Gor, X. Ding, D.R. Karp, N.S. Greenspan, J.C. Poe, T.F. Tedder , J. Immunol , 2005; (175):8011-8023

FcγRIIB mediates C-reactive protein inhibition of endothelial NO synthase

C. Mineo, A.K. Gormley, I.S. Yuhanna, S. Osborne-Lawrence, L. L. Gibson, L. Hahner, R.V. Shohet, S. Black, J.E. Salmon, D. Samols, D.R., Karp, G.D. Thomas, P. W. Shaul , Circ. Res , 2005; (97):1124-1131

Professional Associations/Affiliations

American Association of Immunologists

American College of Physicians

American College of Rheumatology