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Kristine Kamm, PhD
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-645-6000
Biography
Dr. Kamm’s research at UT Southwestern involves aspects of muscle biology and cell motility. In studies of vascular, airway and visceral smooth muscle she has concentrated on relating mechanical events of contraction and relaxation to the generation of biochemical intermediates that regulate contractility. Smooth muscle contraction and aspects of cell motility such as cytokinesis and locomotion result from the action of the motor protein myosin II on the actin cytoskeleton. Smooth and non-muscle isoforms of myosin II are regulated by phosphorylation of their regulatory light chains, owing in part or whole to the activity of calcium/calmodulin-dependent myosin light chain kinase (MLCK).
The activation of MLCK by binding of calcium/calmodulin is assessed by fluorescence resonance energy transfer in tissues from transgenic mice expressing chimeric constructs of MLCK labeled with variants of green fluorescent protein. To determine which aspects of actomyosin-dependent contraction and cell motility require MLCK activity, targeted gene ablation approaches are used. These studies of smooth muscle contraction bear on the pathophysiology of hypertension, asthma and premature labor. In addition, studies of cell migration and division elucidate aspects of the coronary vascular response to injury that leads to restenosis following angioplasty.
Education
| Graduate School | University of Missouri-Columbia (1977) |
| Undergraduate | Stephens College (1972) |
Research Interests
Publications
Stull JT, Hsu LC, Tansey MG, Kamm KE , J Biol Chem , September 1990; (265(27)):16683-90
Lau KS, Grange RW, Isotani E, Sarelius IH, Kamm KE, Huang PL, Stull JT , Physiol Genomics , January 2000; (2(1)):21-7
Kamm KE, Stull JT , Science , April 1986; (232(4746)):80-2
Zhi G, Ryder JW, Huang J, Ding P, Chen Y, Zhao Y, Kamm KE and Stull JT , Proc Nat Acad Sci (USA) , 2005; (102):17519-17524
Isotani E, Zhi G, Lau KS, Huang J, Mizuno Y, Persechini A, Geguchadze R, Kamm KE, Stull JT. , Proc Nat Acad Sci (USA) , 2004; (101):6279-6284
Ding, HL, JW Ryder, JT Stull and KE Kamm , J Biol Chem , June 2009; (284):15541-8
Huang J, Shelton JM, Richardson JA, Kamm KE, Stull JT. , J Biol Chem , 2008; (283):19748-56
Darabi, R, K Gehlback, RM Bachoo, S Kamatgh, M Osowa, KE Kamm, M Kyba, RCR Perlingeiro , Nature Med , 2008; (14):134-143
He W, Peng YJ, Zhang, WC, Lu N, Tang J, Chen C, Zhang CH, Gao S, Chen HQ, Zhi G, Feil R, Kamm KE, Stull, JT, Gao X, Zhu MS , Gastroenterology , 2008; (135):610-620
Mizuno Y, Isotani E, Huang J, Ding H, Stull JT, Kamm KE , Am J Physiol Cell Physiol. , 2008; (295):C358-C364
Related Links
Honors/Awards
(2008)
(1996)
(1984)
(1979)
(1972)