Rolf Joho, PhD

Professor
Endowed Title: Earl A. Forsythe Chair in Biomedical Science
Neuroscience
Graduate Program: Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1800
Office Fax: 214-648-1801

rolf.joho@utsouthwestern.edu

Education

Graduate SchoolUniversity of Zurich - Switzerland (1976)

Research Interests

Biophysics of ion channels
Molecular and cellular basis of normal and pathological behavior
Molecular neuroscience

Publications

Featured
Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3.

Espinosa, F., McMahon, A., Chan, E., Wang, S., Ho, C.S., Heintz, N. and Joho, R.H. , Journal of Neuroscience , 2001; (21):6657-6665

Featured
Pleiotropic effects of a disrupted K+ channel gene: Reduced body weight, impaired motor skill and muscle contraction, but no seizures.

Ho, C.S., Grange, R.W. and Joho, R.H. , Proc. Natl. Acad. Sci. U.S.A. , 1997; (94):1533-1538

Featured
Exchange of conduction pathways between two related potassium channels.

Hartmann, H.A., Kirsch, G.E., Drewe, J.A., Taglialatela, M., Joho, R.H. and Brown, A.M. , Science , 1991; (251):942-944

Featured
A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning.

Frech, G.C., VanDongen, A.M.J., Schuster, G., Brown, A.M. and Joho, R.H. , Nature , 1989; (340):642-645

Purkinje cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants.

Hurlock, E.C., McMahon, A. and Joho, R.H. , Journal of Neuroscience , 2008; (28):4640-4648

Ablation of Kv3.1 and Kv3.3 potassium channels disrupts thalamocortical oscillations in vitro and in vivo.

Espinosa, F., Torres-Vega, M.A., Marks, G.A. and Joho, R.H. , Journal of Neuroscience , 2008; (28):5570-5581

Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice.

Joho, R.H., Street, C., Matsushita, S. and Knopfel, T. , Genes, Brain and Behavior , 2006; (5):472-482

Kv3 potassium channels control the duration of different arousal states by distinct stochastic and clock-like mechanisms.

Joho, R.H., Marks, G.A. and Espinosa, F. , European Journal of Neuroscience , 2006; (23):1567-1574

Altered olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3.

McMahon, A., Fowler, S.C., Perney, T.M., Akemann, W., Knopfel, T. and Joho, R.H. , European Journal of Neuroscience , 2004; (19):3317-3327