John Johnston, PhD

Professor Emeritus
Endowed Title: Ashbel Smith Professor
Biochemistry
Graduate Program: Biological Chemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

john.johnston@utsouthwestern.edu

Education

Graduate SchoolColorado State University (1953)
UndergraduateHastings College (1949)

Research Interests

Molecular mechanisms of macular degeneration
PAF in the development of necrotizing enterocolitis of the newborn and its role in age related macular degeneration
Platelet-activating factor (PAF)
Role of PAF in reproduction and development including sperm motility, ovulation, fertilization,implantation, fetal lung maturation, and parturition

Publications

Featured
Metabolism of platelet-activating factor in rat epididymal spermatozoa.

Muguruma K, JM Johnston , Biol Reprod , 1997; (56):529-536

Featured
Determinants of platelet-activating factor acetylhydrolase: Heritability and relationship to plasma lipoproteins.

Guerra R, B Zhao, V Mooser, D Stafforini, JM Johnston, JC Cohen , J Lipid Res , 1997; (38):2281-2288

Featured
Platelet-activating factor and platelet-activating factor acetylhydrolase activity in rat uterus and placenta during the latter stages of pregnancy.

Matsubara T, K Yasuda, JM Johnston, M Sanezumi, H Okada, S Matsuoka, H Kanzaki , Biol Reprod , 1997; (56):885-890

Featured
Platelet-activating factor in human decidua: Its role in parturition and preterm labor.

Narahara H, I Miyakawa, JM Johnston , Trophoblast Res , 1997; (9):99-107

Featured
Prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase.

Muguruma K, Furukawa M, Tjoelker LW, Dietsch G, Gray PW, Zhao B, Johnston JM. , Adv Exp Med Biol , 1996; (416):129-133

Platelet-Activating Factor Inhibits the Secretion of Platelet-Activating Factor Acetylhydrolase by Human Decidual Macrophages.

Narahara H,Y Kawano,K Nasu, J Yoshimatsu, JM Johnston, I Miyakawa , J Clin Endocrinol Metab. , 2003; (88):6029-6033

Effect of Colony-Stimulating Factors on the Secretion of Platelet-Activating Factor by Decidual Macrophages.

Narahara H, s-c Mine, Y Kawano. JM Johnston , Obstet Gynecol. , 2003; (188):157-161

Identification of platelet-activating factor acetylhydrolase II in human skin.

Marques, M., Pei, Y., Southall, M.D., Johnston, J.M., Arai, H., Aoki, J., Inoue, T., Seltmann, H., Zouboulis, C.C., Travers, J.B., Narahara, H., Mine, S-C., and Kawano, Y. , J Invest Dermatol , 2002; (119):913-919

Inhibitory effect of interleukin-8 on the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages.

Kawano, Y. , Narahara, H., and Johnston, J.M. , J Soc Gyn Invest , 1999; (6):328-332

Role of PAF in cervical softing and sperm motility.

Narahara, J., and Johnston, J.M. , In Press , ;

Honors/Awards

Hastings College

Distinguished Alumni Award (1988)

American Oil Chemist Symposium

Presidential Award (1984)

UT Southwestern (Endowed Chair)

Frank C. Erwin, Jr., Professor of Biochemical Obstetrics (1981)

The American College of Obstetrics and Gynecologists

Purdue Frederick Award (1976)

Professional Associations/Affiliations

Alpha Omega Alpha (Honarary Medical Society)

American Association for the Advancement of Science

American Chemical Society

American Society of Biochemistry and Molecular Biology

Sigma Xi