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Jane Johnson, PhD
Neuroscience
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-648-1870
Office Fax: 214-648-1801
Biography
Dr. Johnson obtained her B.S. in Chemistry (1983) and her Ph. D. in Biochemistry (1988) at the University of Washington in Seattle. Her Ph. D. research was with Dr. Stephan Hauschka on muscle development. Postdoctoral research with Dr. David Anderson at the California Institute of Technology in Pasadena led to the discovery of Ascl1 (previously Mash1), an essential transcription factor in neural development. She joined the faculty at the University of Texas Southwestern Medical Center in December 1992 where she is currently a Professor in the Department of Neuroscience.
The research in the Johnson lab is focused on vertebrate nervous system development during the transition from proliferating neural stem cells to differentiating neurons and glia. We use the bHLH family of transcription factors to probe the molecular mechanisms controlling the balance of neural progenitor cell maintenance and differentiation, and the generation of neuronal diversity. Alteration in function and expression of the neural bHLH factors result in disturbances of connectivity, imbalances in excitatory and inhibitory neuron formation and loss of control of neural cell number. Our focus on understanding how transcription factors regulate neuronal differentiation and diversity has direct implications for stem cell biology and cancer.
Education
| Graduate School | University of Washington (1988) |
| Undergraduate | University of Washington (1983) |
Research Interests
Publications
Glasgow S, Henke RM, Wright C, MacDonald R, and Johnson JE , Development , 2005; (132):5461-5469
Gowan K, Helms AW, Hunsaker T, Collisson T, Ebert PJ, Odom R and Johnson JE , Neuron , 2001; (31):219-232
Helms AW, Abney A, Ben-Arie N, Zoghbi HY and Johnson JE , Development , 2000; (127):1185-1196
Helms AW and Johnson JE , Development , 1998; (125):919-928
Johnson JE, Birren SJ and Anderson DJ , Nature , 1990; (346):858-861
Kim EJ, Hori K, Wyckoff A, Dickel LK, Koundakjian EJ, Goodrich LV, Johnson JE, The Journal of comparative neurology, 2011 May; 519 (7):1355-70
Lai HC, Klisch TJ, Roberts R, Zoghbi HY, Johnson JE, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011 Jul; 31 (30):10859-71
Brzezinski JA, Kim EJ, Johnson JE, Reh TA, Development (Cambridge, England), 2011 Aug; 138 (16):3519-31
Kim EJ, Ables JL, Dickel LK, Eisch AJ, Johnson JE, PloS one, 2011 ; 6 (3):e18472
Miyoshi G, Hjerling-Leffler J, Karayannis T, Sousa VH, Butt SJ, Battiste J, Johnson JE, Machold RP, Fishell G, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010 Feb; 30 (5):1582-94
Related Links
Honors/Awards
(2008)
(1995)