Jer-Tsong Hsieh, PhD

Professor
Endowed Title: Dr. John McConnell Distinguished Chair in Prostate Cancer Research
Jean H. & John T. Walter Jr. Center for Research in Urologic Oncology
Urology
Graduate Program: Cancer Biology
Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3988
Office Fax: 214-648-8786

jt.hsieh@utsouthwestern.edu

Biography

Education: National Taiwan University, Taipei, Taiwan; BS, Plant Pathology; National Yang-Ming Medical School, Taipei, Taiwan; MS, Microbiology and Immunology; University of Wisconsin-Madison, Madison, Wisconsin, PhD, Human Cancer Biology; University of Texas, M.D. Anderson Cancer Center, Houston, Texas, Research Fellow.

Dr. Hsieh is currently an Associate professor and Director of Jean H. and John T. Walter, Jr., Center for Research in Urologic Oncology in the Department of Urology at UT Southwestern. Dr. Hsieh has many years experience in studying tumor biology and cancer progression of urogenital cancers, particularly, prostate and bladder cancers. Currently, his research focuses on translational research with two main topics: one is to identify signal defects leading to androgen-independent prostate cancer progression and bladder cancer metastasis; the other is to develop gene therapeutic modalities. Dr. Hsieh has six nationally funded research grants on these subjects. He is collaborating with Urologists and Medical Oncologists for future clinical trials.

Education

Graduate SchoolUniversity of Wisconsin-Madison (1989)

Research Interests

Bladder cancer gene therapy
Prostate stem cell
Signal network defects in prostate cancer
Small molecular therapy

Publications

Featured
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer

Chen H, Tu SW, Hsieh JT , JBC , June 2005; (280):22437-22444

Featured
Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder

Karam, J. A., Shariat, S.F., Huang, H-Y., Ashfaq, R., Shapiro, E., Lotan, Y., Sagalowsky, A.I., and Hsieh, J.T. , Clin. Cancer Res. , 2007; (13):4400-4406

Featured
Inhibition of mitogens-elicited signal transduction and growth in prostate cancer with a small peptide derived from the functional domain of DOC-2/DAB2 delivered by a unique vehicle

Zhou, J., Fan, J., and Hsieh, J.T. , Cancer Res. , 2006; (66):8822-8828

Featured
Mechanism of increased coxsackie and adenovirus receptor gene expression and adenovirus uptake by phytoestrogen and histone deacetykase inhibitor in human bladder cancer cells and the potential clinical application

Pong, R.C., Roark, R., Ou, J., Fan, J., Stanfield, J., Frenkel, E., Sagalowsky, A., and Hsieh, J.T. , Cancer Res. , 2006; (66):8822-8828

Featured
The Potential Application of Epigenetic Modifiers in the Treatment of Prostate and Bladder Cancer

Zhang, Z., Karam, J., Frenkel, E.P., Sagalowsky, A., and Hsieh, J.T. , Urologic Oncol. , 2006; (24):152-160

A histone deacetylase inhibitor enhances adenoviral infection of renal cancer cells

Okegawa, T., Sayne, J.R., Nutahara, K., Pong, R.C., Saboorian, H., Kabbani, W., Higashihara, E., and Hsieh, J.T. , J. Urol. , 2007; (177):1163-1168

The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-Azacytidine in human bladder cancer therapy

Karam, J.A., Fan, J., Stanfield, J., Richer, E., Benaim, E.A., Frenkel, E.P., Sagalowsky, A.I., Antich, P.P., Mason, R.P., and Hsieh, J.T. , Int. J. Cancer , 2007; (120):1795-1802

Histone deacetylase inhibitor (FK228) enhances the therapeutic efficacy of docetaxel in androgen independent prostate cancer

Zhang, Z., Stanfield, J., Frenkel, E.P., and Hsieh, J.T. , Urol. , 2007; :In press

Cloning of mDAB2IP gene, a novel member of the RasGTPase-activating protein family and characterization of its regulatory region

Chen, H, Karam. J.A., Schultz, R., Zhang, Z., Ducan, C., and Hsieh, J.T. , DNA and Cell Biol. , 2006; (25):232-245

The mechanism of antiandrogen effect of DOC-2/DAB2 on androgen receptor-mediated cell growth in androgen independent prostate cancer

Zhou, J., Hernandez, G., Tu, S., Huang, C.L., Tseng, C.P., and Hsieh, J.T. , Cancer Res. , 2005; (65):9906-9913

Honors/Awards

Dr. John McConnell Distinguished Chair in Prostate Cancer Research

(2007)

Visiting Professor

Xi?an Jiaotong University (2003)

Visiting Professor

The Prostate Center at Vancouver General Hospital (2001)

SBUR/Merck Young Investigator Award

(1997)

Professional Associations/Affiliations

American Association for Cancer Research

American Urological Association

Phi Tau Phi Scholastic Honor Society

Society of Basic Urologic Research

Society of Chinese Bioscientists in America