Yiu Ho, PhD

Assistant Professor
Molecular Genetics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2141
Office Fax: 214-648-8804

yiu.ho@utsouthwestern.edu

Education

Graduate SchoolUniversity of California-Davis (1970)
UndergraduateUniversity of California-Davis (1965)

Research Interests

Cholesterol Metabolism
Monoclonal Antibodies

Publications

Molecular mechanisms of autosomal recessive hypercholesterolemia.

Wilund, K.R., Ming, Y., Campagna, F., Arca, M., Zuliani, Fellin, R., Ho, Y.K., Garcia, J.V., Hobbs, H.H. and Cohen, J.C. , Hum. Mol. Genet. , November 2002; (11):3019-3030

Hairpin orientation of sterol regulatory element binding protein-2 in cell membranes as determined by protease protection.

Hua, X., Sakai, J., Ho, Y.K., Goldstein, J.L. and Brown, M.S. , Journal of Biological Chemistry , December 1995; (270):29422-29427

Mechanism of LDL Binding and Release Probed By Structure-Based Mutagenesis of the LDL Receptor.

Huang, S., Henry, L., Ho, Y.K., Pownall, H.J., Rudenko, G. , J. Lipid Res. , August 2009; (Epub ahead of Print)

Identification of complexes between the COOH-terminal domains of sterol regulatory element binding proteins (SREBPs) and SREBP cleavage-activating protein (SCAP).

Sakai, J., Nohturfft, A., Cheng, D., Ho, Y.K., Brown, M.S., and Goldstein, J.L. , Journal of Biological Chemistry , August 1997; (272):20213-20221

The SREBP pathway in Drosophila: Regulation by palmitate, not sterols.

Seegmiller, A.C., Dobrosotskaya, I., Goldstein, J.L., Ho, Y.K., Brown, M.S., and Rawson, R.B. , Developmental Cell , 2002; (2):1-20