Robert Hammer, PhD

Professor
Endowed Title: Graydon Heartsill Professorship in Medical Science
Biochemistry
Graduate Program: Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

robert.hammer@utsouthwestern.edu

Education

Graduate SchoolWayne State University (1981)

Research Interests

In vivo models of cancer
Oncogene and growth factor collaboration in cancer
Regulation of growth and proliferation
Regulation of liver growth

Publications

Featured
Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders.

Hammer, R.E., Maika, S.D., Richardson, J.A., Tang, J.P., and Taurog, J.D. , Cell , 1990; (63):1099-1112

Featured
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.

Hofmann, S.L., Russell, D.W., Brown, M.S., Goldstein, J.L., and Hammer, R.E. , Science , 1988; (239):1277-1281

Featured
Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth.

Hammer, R.E., Brinster, R.L., Rosenfeld, M.G., Evans, R.M., and Mayo, K.E. , Nature , 1985; (315):413-416

Featured
Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene.

Hammer, R.E., Palmiter, R.D., and Brinster, R.L. , Nature , 1984; (311):65-67

Featured
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes.

Palmiter, R.D., Brinster, R.L., Hammer, R.E., Trumbauer, M.E., Rosenfeld, M.G., Birnberg, N.C., and Evans, R.M. , Nature , 1982; (300):611-615

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

Engelking, L.J., Kuriyama, H, Hammer, R.E., Horton, J. D., Brown, M.S.,Goldstein, J. L. and Liang, G , J. Clinical Investigation , Spring 2004; (113):1168-75

Overexpression of sterol regulatory element-binding protein 1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver

Horton, J. D., Shiomorura, I., Ikemoto, S.,Bashmakov, Y., and Hammer, R.E. , J. Biological Chemistry , 2003; (278):36652-60

Induction of hepatocyte proliferation and death by modulation of T-Antigen expression.

Comerford, S.A., Clouthier, D.E., Hinnant, E., and Hammer, R.E. , Oncogene , 2003; (22):2515-2530

Regualtion of cytosolic phosphoenolpyruvate carboxykinase gene expression in adipocytes

Beale, E.G., Forest, C., and Hammer, R.E. , Biochimie , 2003; (85):1207-11

Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice.

Clouthier, D.E., Comerford, S.A., and Hammer, R.E. , J. Clin. Invest. , 1997; (100):2697-2713

Honors/Awards

Jackson Laboratory, Bar Harbor, ME

Scientific Advisory Bard of Induced Mutant Resource (1996)

State Capital of Wiesbaden, Germany

Carol-Nachman Prize in Rheumatology (1992)

USDA Unit Award for Distinguished Service

Application of Gene Transfer to Farm Animals (1989)

University of Pennsylvania School of Veterinary Medicine

NIH Postdoctoral Fellowship (1983)

Professional Associations/Affiliations

American Association for the Advancement of Science

American Society of Cell Biology

Society for Developmental Biology