Nick Grishin, PhD

Professor
Endowed Title: Virginia Murchison Linthicum Scholar in Biomedical Research 2000-2004
Biochemistry
Graduate Program: Biomedical Engineering
Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

nick.grishin@utsouthwestern.edu

Biography

Dr. Grishin is HHMI Investihgator and Professor of Biochemistry at UT Southwestern. Born and educated in Russia, he received a Diplom (the Russian equivalent of a master’s degree) in biochemistry from the Moscow State University. His doctoral research in molecular biophysics was done with Margaret Phillips at UT Southwestern. After a postdoctoral year with Eugene Koonin at the National Institutes of Health, he joined the faculty at UT Southwestern.

Education

Graduate SchoolUniversity of Texas Southwestern Med Ctr Dallas (1998)
Graduate SchoolMoscow State University - Russia (1993)

Research Interests

We study proteins by means of computational methods

Publications

Featured
Sequence and structure classification of kinases.

Cheek S, Zhang H, Grishin NV. , J Mol Biol , July 2002; (320(4)):855-881

Featured
PROMALS: towards accurate multiple sequence alignments of distantly related proteins.

Pei J, Grishin NV. , Bioinformatics , January 2007; (23(7)):802-808

Featured
Protein structure prediction for the male-specific region of the human Y chromosome.

Ginalski K, Rychlewski L, Baker D, Grishin NV. , Proc Natl Acad Sci U S A , February 2004; (101(8)):2305-2310

Featured
COMPASS: a tool for comparison of multiple protein alignments with assessment of statistical significance.

Sadreyev R, Grishin NV , J Mol Biol , February 2003; (326(1)):317-336

Featured
Fold change in evolution of protein structures.

Grishin, N.V. , J. Struct. Biol. , 2001; (134):167-185

COMPASS server for remote homology inference

Sadreyev RI, Tang M, Kim BH, Grishin NV. , Nucleic Acids Res , May 2007; (35(Web Server issue)):W653

Structural classification of small, disulfide-rich protein domains.

Cheek S, Krishna SS, Grishin NV. , J Mol Biol. , May 2006; (359(1)):215-237

Searching for three-dimensional secondary structural patterns in proteins with ProSMoS.

Shi S, Zhong Y, Majumdar I, Sri Krishna S, Grishin NV. , Bioinformatics , June 2007; (23(11)):1331-1338

A comprehensive system for evaluation of remote sequence similarity detection

Qi Y, Sadreyev RI, Wang Y, Kim BH, Grishin NV. , BMC Bioinformatics , August 2007; (8(1)):314

MUMMALS: multiple sequence alignment improved by using hidden Markov models with local structural information.

Pei J, Grishin NV. , Nucleic Acids Res , August 2006; (34(16)):4364-4374

Honors/Awards

Finn World Travel Award

to attend 12th Symposium of the Protein Society (1998)

UT Southwestern Graduate School

Nominata Award (1998)

Department of Pharmacology

A.G. Gilman award for excellence in research (1997)

GSO Travel Award

to attend XVII Congress of Intl. Union of Crystallography (1996)