Xin Liu, PhD

Assistant Professor
Endowed Title: W.W. Caruth, Jr. Scholar in Biomedical Research 2011-2015
Obstetrics & Gynecology
Graduate Program: Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2493
Office Fax: 214-648-0383

xin.liu@utsouthwestern.edu

Education

Graduate SchoolUniversity of Pennsylvania, Chemistry (2007)
UndergraduateNanjing University - China, Biochemistry (2000)

Research Interests

Chromatin and nuclear organization
Non-coding RNA
Structural biology
Transcriptional regulation

Publications

Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation.

Murakami K, Gibbons BJ, Davis RE, Nagai S, Liu X, Robinson PJ, Wu T, Kaplan CD, Kornberg RD, Proceedings of the National Academy of Sciences of the United States of America, 2012 Mar; 109 (13):4816-21

Lock and Key to Transcription: s-DNA Interaction.

Liu X, Bushnell DA, Kornberg RD, Cell, 2011 Dec; 147 (6):1218-9

Initiation complex structure and promoter proofreading.

Liu X, Bushnell DA, Silva DA, Huang X, Kornberg RD, Science (New York, N.Y.), 2011 Jul; 333 (6042):633-7

Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism.

Liu X, Bushnell DA, Wang D, Calero G, Kornberg RD, Science (New York, N.Y.), 2010 Jan; 327 (5962):206-9

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator.

Liu X, Wang L, Zhao K, Thompson PR, Hwang Y, Marmorstein R, Cole PA, Nature, 2008 Feb; 451 (7180):846-50

Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme.

Li K, Ossareh-Nazari B, Liu X, Dargemont C, Marmorstein R, Journal of molecular biology, 2007 Sep; 372 (1):194-204

Multiple roles for acetylation in the interaction of p300 HAT with ATF-2.

Karanam B, Wang L, Wang D, Liu X, Marmorstein R, Cotter R, Cole PA, Biochemistry, 2007 Jul; 46 (28):8207-16

When viral oncoprotein meets tumor suppressor: a structural view.

Liu X, Marmorstein R, Genes & development, 2006 Sep; 20 (17):2332-7

A mechanism-based inactivator for histone demethylase LSD1.

Culhane JC, Szewczuk LM, Liu X, Da G, Marmorstein R, Cole PA, Journal of the American Chemical Society, 2006 Apr; 128 (14):4536-7

Honors/Awards

CPRIT Scholar in Cancer Research

Cancer Prevention Research Institute of Texas (2011)

W.W. Caruth, Jr. Scholar in Biomedical Research

UT Southwestern Medical Center (2011)

Jane Coffin Childs Postdoctoral Fellowship

The Jane Coffin Childs Memorial Fund for Medical Research (2008)

Dr. Monica H.M. Shander Award

The Wistar Institute (2006)