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Joseph Goldstein, MD
Endowed Title: Julie and Louis A. Beecherl Jr. Distinguished Chair in Biomedical Science
Regental Professorship
Paul J. Thomas Chair in Medicine
Integrative Biology
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-648-2141
Office Fax: 214-648-8804
Biography
Joseph L. Goldstein is currently Chairman of the Department of Molecular Genetics at UT Southwestern Medical Center. In 1985, he was named Regental Professor of the University of Texas. He also holds the Paul J. Thomas Chair in Medicine and the Julie and Louis A. Beecherl Distinguished Chair in Biomedical Science. Dr. Goldstein and his colleague, Michael S. Brown, discovered the low density lipoprotein (LDL) receptor and worked out how these receptors control cholesterol homeostasis. At the basic level, this work opened the field of receptor-mediated endocytosis, and at the clinical level it helped lay the conceptual groundwork for development of drugs called statins that lower blood LDL-cholesterol and prevent heart attacks.
Drs. Goldstein and Brown shared many awards for this work, including the Lasker Award in Basic Medical Research (1985), Nobel Prize in Physiology or Medicine (1985), and National Medal of Science (1988). In recent work, Drs. Goldstein and Brown discovered the SREBP family of transcription factors and showed how these membrane-bound molecules control the synthesis of cholesterol and fatty acids through a newly described process of Regulated Intramembrane Proteolysis. For this work, Drs. Brown and Goldstein received the Albany Medical Center Prize in Medicine and Biomedical Research (2003). Dr. Goldstein is currently Chairman of the Albert Lasker Medical Research Awards Jury and is a member of the Boards of Trustees of the Howard Hughes Medical Institute and The Rockefeller University. He also serves on the Scientific Advisory Boards of the Welch Foundation, Memorial Sloan-Kettering Cancer Center, Scripps Research Institute, Van Andel Institute, and the Massachusetts General Hospital. He is a member of the US National Academy of Sciences and a Foreign Member of the Royal Society.
Education
| Graduate School | University of Texas Southwestern Med Ctr Dallas (1966) |
| Undergraduate | Washington and Lee University (1962) |
Research Interests
Publications
Goldstein, J.L., DeBose-Boyd, R.A. and Brown, M.S. , Cell , 2006; (124):35-46
Radhakrishnan, A., Sun, L.-P., Kwon, H.J., Brown, M.S., and Goldstein, J.L. , Molecular Cell , 2004; (15):259-268
Yang, T., Espenshade, P.J., Wright, M.E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J.L., and Brown, M.S. , Cell , 2002; (110):489-500
Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S., and Goldstein, J.L. , Nature , 1999; (401):73-76
Brown, M.S. and Goldstein, J.L. , Cell , 1997; (89):331-340
Zhao, T.-J., Liang, G., Li, R.L., Xie, X., Sleeman, M.W., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Goldstein, J.L., and Brown, M.S. , Proc. Natl. Acad. Sci. USA , 2010; (107):7467-7472
Wang, M.L., Motamed, M., Infante, R.E., Abi-Moshel, L., Kwon, H.J., Brown, M.S. and Goldstein, J.L. , Cell Metab. , 2010; (12):166-173
Zhao, T.-J., Sakata, I., Li, R.L., Liang, G., Richardson, J.A., Brown, M.S., Goldstein, J.L., and Zigman, J.M. , Proc. Natl. Acad. Sci. USA , 2010; (107):15868-15873
Li, S., Brown, M.S. and Goldstein, J.L. , Proc. Natl. Acad. Sci. USA , 2010; (107):3441-3446
Brown, M.S., Ye, J., and Goldstein, J.L. , Science , 2010; (328):1495-1496
Related Links
Honors/Awards
(2003)
(2000)
(1988)
(1985)
(1985)