Elizabeth Goldsmith, PhD

Professor
Endowed Title: Patti Bell Brown Professorship in Biochemistry
Biochemistry
Graduate Program: Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

elizabeth.goldsmith@utsouthwestern.edu

Education

Graduate SchoolUniversity of California-Los Angeles (1971)
UndergraduateUniversity of California-Los Angeles (1967)

Research Interests

Conformation regulation of protein molecules
Enzyme specificity
Protein design

Publications

Featured
Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b.

Chang, C., Xu, B., Akella, R., Cobb, M.H., and Goldsmith, E.J. , Mol. Cell , 2002; (9):1241-1249

Featured
The structure of a Michaelis Serpin-Protease Complex.

Ye, S., Cech, A., Belmares, R., Bergstrom, R., Corey, D., Kanost, M., and Goldsmith, E.J. , Nature Struct. Biol. , 2001; (8):979-983

Featured
The structure of phosphorylated MAP kinase ERK2 at 2.5 E resolution.

Canagarajah, B., Khokhlatchev, A., Cobb, M.H., and Goldsmith, E.J. , Cell , 1997; (90):859-869

Featured
Allosteric enzymes as models for chemomechanical energy transducing assemblies.

Goldsmith, E.J. , FASEB J. , 1996; (10):702-703

Featured
How MAP kinases are regulated.

Cobb, M.H., and Goldsmith, E.J. , J. Biol. Chem. , 1995; (270):14843-14846

Docking Interactions Induce Exposure of Activation Loop in the MAP Kinase ERK2

Zhou, T, Sun, L, Humphreys, J, and Goldsmith, EJ , Structure , 2006; (6):1011-9

Crystal Structure of the MAP3K TAO2 Kinase Domain Bound by an Inhibitor Staurosporine

Zhou, T, Sun, LG, Gao Y, and Goldsmith, EJ , Acta Biochim Biophys Sin (Shanghai) , 2006; (6):385-92

Crystal Structure of the Kinase Domain of WNK1, a Kinase that Causes a Hereditary Form of Hypertension

X. Min, Byung-Hoon Lee, Malanie H. Cobb, and Elizabeth J. Goldsmith , Structure , 2004; (12):1303-1311

Active Structure of the TAO2 Kinase Domain: Activation and Specificity of a Ste20p MAP3K

T. Zhou, Malavika Raman, Yan Gao, Zhu Chen, Mischa Machius, Melanie H. Cobb, and Elizabeth J. Goldsmith , Structure , 2004; (12):1891-900

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b.

Chang, C., Xu, B., Akella, R., Cobb, M.H., and Goldsmith, E.J. , Mol. Cell , 2002; (9):1241-1249

Honors/Awards

NIH

Postdoctoral Fellowship (1973)

UCLA

Graduate Woman of the Year (1971)

UCLA

Honors in Chemistry (1967)

Professional Associations/Affiliations

American Crystallographic Association

Biophysical Society

Protein Society