Christine Garcia, MD, PhD

Associate Professor
Eugene Mcdermott Center for Human Growth & Development, Internal Medicine
Graduate Program: Genetics and Development
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

christine.garcia@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

FellowshipUniversity of Texas Southwestern (2006)
FellowshipUniversity of Texas Southwestern (2004)
ResidencyUniversity of Texas Southwestern (2001)
InternshipUniversity of Texas Southwestern (2000)
UniversityUniversity of Texas Southwestern (1996)
UniversityUniversity of Texas Southwestern (1996)
UniversityTexas A&M University (1988)

Research Interests

Aging
Familial Pulmonary Fibrosis
Familial Spontaneous Pneumothorax
Genetic Basis of Adult Pulmonary Diseases
Human Genetics

Publications

Featured
Adult-Onset Pulmonary Fibrosis Caused by Mutations in Telomerase

Tsakiri, K.D., Cronkhite, J.T., Kuan, P.J., Raghu, G., Weissler, J.C., Rosenblatt, R.L., Shay, J.W., and Garcia, C.K. , PNAS , May 2007; (104):7552-7557

Featured
Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

Garcia, C.K., Wilund, K., Arca, M., Zuliani, G., Fellin, R., Maioli, M., Calandra, S., Bertolini, S., Cossu, F., Grishin, N., Barnes, R., Cohen, J., and Hobbs, H. , Science , May 2001; (292):1394-1398

Featured
Genetic Defects in Surfactant Protein A2 Associated with Pulmonary Fibrosis and Lung Cancer

Wang, Y., Kuan, P.J., Xing, C., Cronkhite, J.T., Torres, F., Rosenblatt, R.L., DiMaio, J.M., Kinch, L.N., Grishin, N.V. and Garcia, C.K. , American Journal of Human Genetics , January 2009; (84(1)):52-59

Featured
Nonsense Mutations in Folliculin Presenting as Isolated Spontaneous Pneumothorax in Adults.

Graham, Randall B., Nolasco, Melissa, Peterlin, Borut and Garcia, Christine Kim , American Journal of Respiratory and Critical Care Medicine , April 2005; (172):39-44

Human Disease of Telomerase Dysfunction: Insights into Tissue Aging

Garcia, C.K., Wright, W.E. and Shay, J.W. , NAR , October 2007; (35):7406-7416

Telomere Lengths, Pulmonary Fibrosis and Telomerase (TERT) Mutations

Diaz de Leon, A., Cronkhite, J. T., Katzenstein, A.-L., Godwin, J. D., Raghu, G., Glazer C. S., Rosenblatt, R. L., Girod, C. E., Garrity, E. R., Xing, C. and Garcia, C. K. , PLoS One , May 2010; (5(5)):e10680

Molecular Characterization of a Membrane Transporter for Lactate, Pyruvate, and Other Monocarboxylates: Implications for the Cori Cycle

Garcia, C.K., Goldstein, J.L., Pathak, R.K., Anderson, R.G.W., and Brown, M.S. , Cell , March 1994; (76):865-873

Surfactant Protein A2 Mutations Associated with Pulmonary Fibrosis Lead to Protein Instability and ER Stress

Meenakshi, M., Wang, Y., Gerard, R.D., Mendelson, C. and Garcia, C.K. , J. Biol. Chem. , July 2010; (285):22103-22113

Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis

Cronkite, J. T., Xing, C., Raghu, G., Chin, K., Torres, F., Rosenblatt, R. L., and Garcia, C. K. , Am. J. Resp. Crit. Care Med. , July 2008; (178):729-737

Idiopathic pulmonary fibrosis: update on genetic discoveries.

Garcia CK, Proceedings of the American Thoracic Society, 2011 May; 8 (2):158-62

Honors/Awards

Doris Duke Charitable Foundation

Clinical Scientist Development Award (2008)

President’s Research Council

Young Investigator Award (2006)

Charles E. Culpeper Medical Scholar

(2004)

Parker B. Francis Fellowship

(2003)

Alpha Omega Alpha

(1991)