Daniel Foster, MD

Professor
Endowed Title: John Denis McGarry, Ph.D., Distinguished Chair in Diabetes and Metabolic Research
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

daniel.foster@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Foster holds the John Denis McGarry, Ph.D. Distinguished Chair in Diabetes and Metabolic Research in Internal Medicine at the University of Texas Southwestern Medical School at Dallas. A graduate of Southwestern, he took his residency in Internal Medicine at Parkland Memorial Hospital in Dallas before moving to the NIH for a research fellowship. He returned to the faculty following his tenure at the NIH and was elected chair in 1988. Dr. Foster is a member of the American Society for Biochemistry and Molecular Biology, the American Society for Clinical Investigation, the Association of American Physicians and the Institute of Medicine of the National Academy of Sciences. He is a Fellow of the American Academy for the Advancement of Science and a Fellow of the American Academy of Arts and Sciences. He is a Master of the American College of Physicians and recently served as President of the Association of Professors of Medicine. He is currently President of the Academy of Medicine, Engineering and Sciences of Texas. At the National Institutes of Health, he was chair of the Metabolism Study Section, was a member of the NIDDK Advisory Council and served two terms on the Board of Scientific Counselors of the Clinical Center. Dr. Foster's research has focused for many years on the intermediary metabolism of carbohydrates and lipids. With his colleague, J. Denis McGarry, he discovered the malonyl-CoA regulatory system for fatty acid oxidation and ketogenesis, for which he received the Banting Medal. He received the Robert H. Williams Distinguished Chair of Medicine Award of the Associate of Professors of Medicine in February 2001. Dr. Foster was Associate Editor of the Journal of Clinical Investigation from 1972-1977 and was Editor of Diabetes from 1978-1983. He is co-editor (with J.D. Wilson) of the Williams Textbook of Endocrinology and writes for a number of other textbooks.

Education

FellowshipNational Institutes of Health-Research, Endocrinology (1962)
FellowshipUT Southwestern Medical Center at Dallas, Endocrinology (1960)
ResidencyParkland Memorial Hospital, Internal Medicine (1959)
InternshipParkland Memorial Hospital, Internal Medicine (1956)
Medical SchoolUT Southwestern Medical Center at Dallas (1955)

Research Interests

Fatty Acid Oxidation
Intermediary metabolism

Publications

Featured
Cloning sequencing and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function.

Esser V; Britton CH; Weis BC; Foster DW; McGarry JD , Journal of Biological Chemistry , 1993; (268):5817 - 5822

Featured
Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II.

Woeltje KF; Esser V; Weis BC; Sen A; Cox WF; McPhaul MJ; Slaughter CA; Foster DW; McGarry JD , Journal of Biological Chemistry , 1990; (265):10720 - 10725

Featured
Banting Memorial Lecture; From glycogen to ketones - and back.

Foster DW , Diabetes , 1984; (33):1188 - 1199

Featured
In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis.

McGarry JD; Foster DW , Journal of Biological Chemistry , 1979; (254):8163 - 8168

Featured
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

McGarry JD; Mannaerts GP; Foster DW , Journal of Clinical Investigation , 1977; (60):265 - 270

Roles of the amino- and carboxy-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes. Insights from expression of chimeric proteins and mutation of conserved histidine residues

Swanson ST; Foster DW; McGarry JD; Brown NF , Biochem J , 1999; (335):513 - 519

Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B).

Britton CH; Mackey DW; Esser V; Foster DW; Burns DK; Yarnall DP; Froguel P; McGarry JD , Genomics , 1997; (40):209 - 211

Human liver mitochondrial carnitine palmitoyltransferase I: Characterization of its cDNA and chromosomal localization and partial analysis of the gene.

Britton CH; Schultz RA; Zhang B; Esser V; Foster DW; McGarry JD. , Proceedings of the National Academy of Sciences USA , 1995; (92):1984 - 1988

Mitochondrial carnitine palmitoyltransferase I isoform switching in the developing rat heart.

Brown NF; Weis BC; Hustie JE; Foster DW; McGarry JD , Journal of Biological Chemistry , 1995; (270):8952 - 8957

Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme.

Weis BC; Esser V; Foster DW; McGarry JD. , Journal of Biological Chemistry , 1994; (269):18712 - 18715

Honors/Awards

Alpha Omega Alpha Robert J. Glaser Distinguished Teaching Award

(2008)

Eric G. Neilson, M.D., Distinguished Professor Award

Associate of Specialty Professors (2007)

J. Denis McGarry Award for Scientific/Community Excellence

(2007)

The Daniel W. Martin Science Award

(2005)

Great Teacher Award

National Institutes of Health (2002)

Professional Associations/Affiliations

American College of Physicians, Master

American Diabetes Association

American Federation for Medical Research

American Society for Biochemistry & Molecular Biology

Association of American Physicians