J Falck, PhD

Professor
Endowed Title: Robert A. Welch Foundation Distinguished Chair in Chemistry
Biochemistry, Pharmacology
Graduate Program: Biological Chemistry
Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

j.falck@utsouthwestern.edu

Education

Graduate SchoolColorado State University (1973)
UndergraduateColorado State University (1970)

Research Interests

medicinal chemistry
natural products isolation and identification
organometalics
synthetic methodology
total synthesis

Publications

Featured
A 20-Hydroxyeicosatetraenoic Acid Agonist, N-[20-Hydroxyeicosa-5(Z),14-(Z)-Dienoyl]Glycine, Opposes the Fall in Blood Pressure and Vascular Reactivity in Endotoxin-Treated Rats

Tunctan, B., Korkmaz, B., Butaralioglu, C.K., Firat, S.S., Anjaiah, S., Falck, J.R., Roman, R.J., and K.U. Malik , Shock , 2008; (30):329-335

Featured
Enantioselective, Organocatalytic Oxy-Michael Addition to γ/δ-Hydroxy-α,β-enones: Boronate-Amine Complexes as Chiral Hydroxide Synthons

Li, D-R., Murugan, A., and J.R. Falck , J. Am. Chem. Soc. , 2008; (130):46-48

Featured
Synthesis and Sterochemical Assignment of FR252921, a Promising Immunosuppressant

Falck, J.R., He, A., Fukui, H., Tsutsui, H., and A. Radha , Angew. Chem. Int. Ed. , 2007; (46):4527-4529

Featured
Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Panacreatic β Cells

Illies, C., Gromada, J., Fiume, R., Leibiger, B., Yu, J., Juhl, K., Yang, S-N., Barma, D., Falck, J.R., Saiardi, A., Barker, C.J., and P-O Berggren , Science , 2007; (318):1299-1302

Steroselective Synthesis of Methyl (Z)-α-Methoxyacrylates via Two-Carbon Homologation of Aldehydes

Baati, R., Mioskowski, C., Kashinath, D., Kodepelly, S., Lu, B., and J.R. Falck. , Tetrahedron Lett. , 2009; (50):402-405

Synthesis of Enantioenriched α-(Hydroxyalkl)-tri-n-butylstannanes

He, A., and J.R. Falck , Angew. Chem. Int. Ed. , 2008; (47):6586-6589

Targeting QseC Signaling and Virulence for Antibiotic Development

Rasko, D.A., Moriera, C.G., Li, D.R., Readings, N.C., Ritchie, J.M., Waldor, M.K., William, N., Taussig, R., Wei, S., Roth, M., Hughes, D.T., Huntley, J.F., Fina, M.W., Falck, J.R., and V. Sperandio , Science , 2008; (321):1078-1080

Efficient Iridium-Catalyzed C-H Functionalization/Silylation of Heteroarenes

Lu, B., and J.R. Falck , Angew. Chem. Int. Ed. , 2008; (47):7508-7510

Honors/Awards

American Chemical Society

Wilfred T. Doherty Award (1996)

Winter Eicosanoid Conference

Special Recognition Award (1996)

Phi Kappa Phi Honarary Society

(1973)

National Science Foundation

Trainee (1970)

Professional Associations/Affiliations

American Chemical Society

Royal Society of Chemistry (U.K.)