Daniel Rosenbaum, PhD

Assistant Professor
Endowed Title: Eugene McDermott Scholar in Medical Research 2010-2014
Biochemistry
Graduate Program: Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

dan.rosenbaum@utsouthwestern.edu

Education

Graduate SchoolHarvard University, Chemistry (2005)
UndergraduatePrinceton University, Chemistry (1999)

Research Interests

G protein-coupled receptors
membrane protein structural biology
molecular recognition

Publications

Featured
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

Cherezov*, V., Rosenbaum*, D.M., Hanson, M.A., Rasmussen, S.G.F., Thian, F.S., Kobilka, T.S., Choi, H.J., Kuhn, P., Weis, W.I., Kobilka, B.K., Stevens, R.C. , Science , November 2007; (318(5854)):1258--65

Featured
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

Rosenbaum*, D.M., Cherezov*, V., Hanson, M.A., Rasmussen, S.G.F., Thian, F.S., Kobilka, T.S., Choi, H.J., Yao, X.J., Weis, W.I., Stevens, R.C., Kobilka, B.K.(* contributed equally) , Science , November 2007; (318(5854)):1266-73

Featured
Crystal structure of the human beta2 adrenergic G protein-coupled receptor.

Rasmussen*, S.G.F. Choi*, H.J., Rosenbaum*, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K.(* contributed equally) , Nature , October 2007; (450(7168)):383-7

The structure and function of G-protein coupled receptors.

Rosenbaum, D.M., Rasmussen, S.G.F., Kobilka, B.K. , Nature , May 2009; (459(7245)):356-63

Structure-based discovery of beta2-adrenergic receptor ligands

Kolb*, P., Rosenbaum*, D.M., Irwin, J.J., Fung, J.J., Kobilka, B.K., Shoichet, B.K.(* equal contributions) , Proc Natl Acad Sci USA , April 2009; (106(16)):6843-8

Honors/Awards

NIH NRSA Postdoctoral Fellowship

(2007)