Mikhail Levin, PhD

Instructor
Department of Clinical Sciences
Download Curriculum Vitae

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

mikhail.levin@utsouthwestern.edu

Education

Graduate SchoolOhio State University-Main Campus (2002)
Graduate SchoolOhio State University-Main Campus, Biochemistry (1999)

Research Interests

Adaptive immune response
Image analysis
Mechanism-based computational models and their validation
Nucleic acids: synthesis, unwinding, repair
Semantic Web technologies

Publications

The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase.

Rajagopal V, Gurjar M, Levin MK, Patel SS, The Journal of biological chemistry, 2010 Jun; 285 (23):17821-32

Experimental and computational analysis of DNA unwinding and polymerization kinetics.

Pandey M, Levin MK, Patel SS, Methods in molecular biology (Clifton, N.J.), 2010 ; 587:57-83

Mechanism of cadmium-mediated inhibition of Msh2-Msh6 function in DNA mismatch repair.

Wieland M, Levin MK, Hingorani KS, Biro FN, Hingorani MM, Biochemistry, 2009 Oct; 48 (40):9492-502

Mechanism of ATP-driven PCNA clamp loading by S. cerevisiae RFC.

Chen S, Levin MK, Sakato M, Zhou Y, Hingorani MM, Journal of molecular biology, 2009 May; 388 (3):431-42

Model-based global analysis of heterogeneous experimental data using gfit.

Levin MK, Hingorani MM, Holmes RM, Patel SS, Carson JH, Methods in molecular biology (Clifton, N.J.), 2009 ; 500:335-59

Multiplexed RNA trafficking in oligodendrocytes and neurons.

Carson JH, Gao Y, Tatavarty V, Levin MK, Korza G, Francone VP, Kosturko LD, Maggipinto MJ, Barbarese E, Biochimica et biophysica acta, 2008 Aug; 1779 (8):453-8

Multiplexed dendritic targeting of alpha calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway.

Gao Y, Tatavarty V, Korza G, Levin MK, Carson JH, Molecular biology of the cell, 2008 May; 19 (5):2311-27

Significant proportions of nuclear transport proteins with reduced intracellular mobilities resolved by fluorescence correlation spectroscopy.

Paradise A, Levin MK, Korza G, Carson JH, Journal of molecular biology, 2007 Jan; 365 (1):50-65

DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase.

Stano NM, Jeong YJ, Donmez I, Tummalapalli P, Levin MK, Patel SS, Nature, 2005 May; 435 (7040):370-3

A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase.

Levin MK, Gurjar M, Patel SS, Nature structural & molecular biology, 2005 May; 12 (5):429-35

Books

Kinetic analysis of macromolecules a practical approach (Transient-state kinetics and computational analysis of transcription initiation)

S.S. Patel, R.P. Bandwar, M.K. Levin, Oxford University Press2002

Molecular Motors (Helicases as Molecular Motors)

M.K. Levin, S.S. Patel, Wiley-VCH Verlag GmbH & Co. KGaA2004