Ronald Estabrook, PhD

Professor Emeritus
Endowed Title: Ashbel Smith Professor
Biochemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

ronald.estabrook@utsouthwestern.edu

Education

Graduate SchoolRochester Institute of Technology (1954)
UndergraduateRensselaer Polytechnic Institute (1950)

Research Interests

History of Biochemical reactions Related to Steroid Hormone Biosynthesis
History of Biological Electron Transport Systems

Publications

Featured
High level expression of functional human cytochrome P450 1A2 in Escherica coli.

Fisher, C.W., Caudle, D.L., Martin-Wixtrom, C., Quattrochi, L.C., Tukey, R.H., Waterman, M.R., and Estabrook, R.W. , FASEB J. , 1992; (6):759-764

Featured
Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system.

Kuthan, H., Tsuji, H., Graf, H., Ullrich, V., Werringloer, J., and Estabrook, R.W. , FEBS Letters , 1978; (91):343-345

Featured
Photochemical action spectrum of the terminal oxidase of mixed function oxidase systems.

Cooper, D.Y., Levin, S., Narasimhulu, S., Rosenthal, O. and Estabrook, R.W. , Science , 1965; (147):400-402

Featured
Studies on the content and organization of the respiratory enzymes of mitochondria.

Estabrook, R.W., and Holowinsky, A. , J. Biophys, Biochem. Cytol. , 1961; (9):19-28

Featured
The low temperature spectra of hemoproteins. I. Apparatus and its application to a study of cytochrome c.

Estabrook,R.W. , J. Biol. Chem. , 1956; (223):781-794

5(alpha)-Androstane-3(alpha), 17(beta)-Diol is formed in Tammar Wallaby Pouch Young Testes by a Pathway involving 5(alpha)-Pregnane-3(alpha), 17(alpha)-Diol-20-One as a Key Intermediate.

Wilson, J.D., Auchus, R.J., Leihy, M.W., Guryev, O.L., Estabrook, R.W., Osborn, S.M., Shaw G., and Renfree, M.B. , Endocrinology , 2002; (144):575-580

Probing the Interaction of Bovine Cytochrome P450scc (CYP11A1) with Adrenodoxin: Evaluating Site-directed Mutations by Molecular Modeling.

Usanov, S.A., Graham, S.E., Lepesheva, G.I., Azeva, T.N., Strushkevish, N.V., Gilep, A.A., Estabrook, R.W., and Peterson, J.A. , Biochemistry , 2002; (41):8310-8320

Apo-cytochrome b5 as an Indicator of Changes in Heme Accessability: Preliminary Studies with Cytochrome P450 3A4.

Gilep, A.A., Guryev, O.L., Usanov, S.A., and Estabrook, R.W. , J. Inorganic Biochem. , 2001; (87):237-244

An Enzymatically Active Chimeric Protein Containing the Hydrophilic Form of NADPH-Cytochrome P450 Reductase Fused to the Membrane-binding Domain of Cytochrome b5.

Gilep, A.A., Guryev, O.L., Usanov, S.A., and Estabrook, R.W. , Biochem. Biophys. Res. Commun. , 2001; (284):937-941

Cloning and heterologous expression of the cDNA encoding the cytochrome P459 steroid 17alpha-hydroxylase/17,20 lyase from bison.

Gilep, A.A., Huryeva, I.V., Guryev, O.L., Usanov, S.A. and Estabrook, R.W. , GeneBank , 2000; (AF292526)

Honors/Awards

Oxygen Society of California

Honarary Member (1998)

International Society for the Study of Xenobiotics

Lifetime Honarary Member (1994)

American Chemical Society

Dougherty Award Recipient (1981)

FASEB

Distinguished Scientist Award (1977)

National Academy of Sciences

Elected to Institute of Medicine (1975)

Professional Associations/Affiliations

American Chemical Society

American Soceity of Biochemistry and Molecular Biology

American Society of Pharmacology and Experimental Therapeutics

Society of Sigma Xi

Society of Toxicology